Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)
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| Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction | Replicate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selumetinib | WM1552C | 3.1600 | uM | 72 | hr | 2160 | 402 | 0.3410 | 0.4106 | 0.1861 | 0.1902 | 3 |
| Selumetinib | WM1552C | 3.1600 | uM | 72 | hr | 2439 | 448 | 0.3862 | 0.4106 | 0.1837 | 0.1902 | 4 |
| Vemurafenib | WM1552C | 0.0032 | uM | 24 | hr | 2320 | 166 | 0.8597 | 0.9196 | 0.0716 | 0.0617 | 1 |
| Vemurafenib | WM1552C | 0.0032 | uM | 24 | hr | 2588 | 134 | 0.9794 | 0.9196 | 0.0518 | 0.0617 | 2 |
| Vemurafenib | WM1552C | 0.0032 | uM | 24 | hr | 3 | ||||||
| Vemurafenib | WM1552C | 0.0032 | uM | 24 | hr | 4 | ||||||
| Vemurafenib | WM1552C | 0.0032 | uM | 48 | hr | 3144 | 254 | 0.9193 | 0.9247 | 0.0808 | 0.0780 | 1 |
| Vemurafenib | WM1552C | 0.0032 | uM | 48 | hr | 3159 | 222 | 0.9343 | 0.9247 | 0.0703 | 0.0780 | 2 |
| Vemurafenib | WM1552C | 0.0032 | uM | 48 | hr | 3105 | 222 | 0.9171 | 0.9247 | 0.0715 | 0.0780 | 3 |
| Vemurafenib | WM1552C | 0.0032 | uM | 48 | hr | 3205 | 287 | 0.9282 | 0.9247 | 0.0895 | 0.0780 | 4 |
| Vemurafenib | WM1552C | 0.0032 | uM | 72 | hr | 6258 | 509 | 1.1151 | 1.0630 | 0.0813 | 0.0880 | 1 |
| Vemurafenib | WM1552C | 0.0032 | uM | 72 | hr | 6659 | 587 | 1.1777 | 1.0630 | 0.0882 | 0.0880 | 2 |
| Vemurafenib | WM1552C | 0.0032 | uM | 72 | hr | 5424 | 514 | 0.9524 | 1.0630 | 0.0948 | 0.0880 | 3 |
| Vemurafenib | WM1552C | 0.0032 | uM | 72 | hr | 5690 | 499 | 1.0069 | 1.0630 | 0.0877 | 0.0880 | 4 |
| Vemurafenib | WM1552C | 0.0100 | uM | 24 | hr | 2678 | 181 | 0.9966 | 0.9693 | 0.0676 | 0.0655 | 1 |
| Vemurafenib | WM1552C | 0.0100 | uM | 24 | hr | 2520 | 160 | 0.9419 | 0.9693 | 0.0635 | 0.0655 | 2 |
| Vemurafenib | WM1552C | 0.0100 | uM | 24 | hr | 3 | ||||||
| Vemurafenib | WM1552C | 0.0100 | uM | 24 | hr | 4 | ||||||
| Vemurafenib | WM1552C | 0.0100 | uM | 48 | hr | 3589 | 247 | 1.0631 | 1.0025 | 0.0688 | 0.0701 | 1 |
| Vemurafenib | WM1552C | 0.0100 | uM | 48 | hr | 3234 | 185 | 0.9699 | 1.0025 | 0.0572 | 0.0701 | 2 |
| Vemurafenib | WM1552C | 0.0100 | uM | 48 | hr | 3326 | 272 | 0.9715 | 1.0025 | 0.0818 | 0.0701 | 3 |
| Vemurafenib | WM1552C | 0.0100 | uM | 48 | hr | 3408 | 247 | 1.0055 | 1.0025 | 0.0725 | 0.0701 | 4 |
| Vemurafenib | WM1552C | 0.0100 | uM | 72 | hr | 6333 | 428 | 1.1454 | 1.1384 | 0.0676 | 0.0756 | 1 |
| Vemurafenib | WM1552C | 0.0100 | uM | 72 | hr | 6677 | 400 | 1.2175 | 1.1384 | 0.0599 | 0.0756 | 2 |
| Vemurafenib | WM1552C | 0.0100 | uM | 72 | hr | 5829 | 522 | 1.0294 | 1.1384 | 0.0896 | 0.0756 | 3 |