Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)
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| Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction | Replicate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selumetinib | RVH-421 | 0.0100 | uM | 24 | hr | 4 | ||||||
| Selumetinib | RVH-421 | 0.0100 | uM | 48 | hr | 1661 | 129 | 0.8005 | 0.8836 | 0.0777 | 0.0601 | 1 |
| Selumetinib | RVH-421 | 0.0100 | uM | 48 | hr | 1600 | 112 | 0.7775 | 0.8836 | 0.0700 | 0.0601 | 2 |
| Selumetinib | RVH-421 | 0.0100 | uM | 48 | hr | 1920 | 93 | 0.9546 | 0.8836 | 0.0484 | 0.0601 | 3 |
| Selumetinib | RVH-421 | 0.0100 | uM | 48 | hr | 2006 | 89 | 1.0016 | 0.8836 | 0.0444 | 0.0601 | 4 |
| Selumetinib | RVH-421 | 0.0100 | uM | 72 | hr | 8827 | 231 | 0.9850 | 0.9881 | 0.0262 | 0.0321 | 1 |
| Selumetinib | RVH-421 | 0.0100 | uM | 72 | hr | 9833 | 326 | 1.0894 | 0.9881 | 0.0332 | 0.0321 | 2 |
| Selumetinib | RVH-421 | 0.0100 | uM | 72 | hr | 8078 | 275 | 0.8941 | 0.9881 | 0.0340 | 0.0321 | 3 |
| Selumetinib | RVH-421 | 0.0100 | uM | 72 | hr | 8900 | 313 | 0.9840 | 0.9881 | 0.0352 | 0.0321 | 4 |
| Selumetinib | RVH-421 | 0.0316 | uM | 24 | hr | 1498 | 62 | 1.0388 | 1.0320 | 0.0414 | 0.0442 | 1 |
| Selumetinib | RVH-421 | 0.0316 | uM | 24 | hr | 1487 | 70 | 1.0251 | 1.0320 | 0.0471 | 0.0442 | 2 |
| Selumetinib | RVH-421 | 0.0316 | uM | 24 | hr | 3 | ||||||
| Selumetinib | RVH-421 | 0.0316 | uM | 24 | hr | 4 | ||||||
| Selumetinib | RVH-421 | 0.0316 | uM | 48 | hr | 1654 | 120 | 0.8015 | 0.7947 | 0.0726 | 0.0622 | 1 |
| Selumetinib | RVH-421 | 0.0316 | uM | 48 | hr | 1470 | 110 | 0.7106 | 0.7947 | 0.0748 | 0.0622 | 2 |
| Selumetinib | RVH-421 | 0.0316 | uM | 48 | hr | 1711 | 83 | 0.8506 | 0.7947 | 0.0485 | 0.0622 | 3 |
| Selumetinib | RVH-421 | 0.0316 | uM | 48 | hr | 1649 | 87 | 0.8162 | 0.7947 | 0.0528 | 0.0622 | 4 |
| Selumetinib | RVH-421 | 0.0316 | uM | 72 | hr | 7549 | 228 | 0.8389 | 0.8489 | 0.0302 | 0.0318 | 1 |
| Selumetinib | RVH-421 | 0.0316 | uM | 72 | hr | 9042 | 260 | 1.0063 | 0.8489 | 0.0288 | 0.0318 | 2 |
| Selumetinib | RVH-421 | 0.0316 | uM | 72 | hr | 6722 | 240 | 0.7428 | 0.8489 | 0.0357 | 0.0318 | 3 |
| Selumetinib | RVH-421 | 0.0316 | uM | 72 | hr | 7284 | 238 | 0.8074 | 0.8489 | 0.0327 | 0.0318 | 4 |
| Selumetinib | RVH-421 | 0.1000 | uM | 24 | hr | 1476 | 71 | 1.0164 | 1.0323 | 0.0481 | 0.0496 | 1 |
| Selumetinib | RVH-421 | 0.1000 | uM | 24 | hr | 1527 | 78 | 1.0482 | 1.0323 | 0.0511 | 0.0496 | 2 |
| Selumetinib | RVH-421 | 0.1000 | uM | 24 | hr | 3 | ||||||
| Selumetinib | RVH-421 | 0.1000 | uM | 24 | hr | 4 |