Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)
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| Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction | Replicate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AZ-628 | LOXIMVI | 1.0000 | uM | 24 | hr | 1994 | 157 | 0.7502 | 0.8617 | 0.0787 | 0.0677 | 3 |
| AZ-628 | LOXIMVI | 1.0000 | uM | 24 | hr | 2066 | 136 | 0.7881 | 0.8617 | 0.0658 | 0.0677 | 4 |
| AZ-628 | LOXIMVI | 1.0000 | uM | 48 | hr | 1975 | 1.1792 | 1.2276 | 0.1119 | 0.1176 | 1 | |
| AZ-628 | LOXIMVI | 1.0000 | uM | 48 | hr | 2028 | 1.2028 | 1.2276 | 0.1179 | 0.1176 | 2 | |
| AZ-628 | LOXIMVI | 1.0000 | uM | 48 | hr | 2138 | 1.2720 | 1.2276 | 0.1151 | 0.1176 | 3 | |
| AZ-628 | LOXIMVI | 1.0000 | uM | 48 | hr | 2137 | 1.2565 | 1.2276 | 0.1254 | 0.1176 | 4 | |
| AZ-628 | LOXIMVI | 1.0000 | uM | 72 | hr | 1951 | 0.9396 | 0.9619 | 0.2004 | 0.2106 | 1 | |
| AZ-628 | LOXIMVI | 1.0000 | uM | 72 | hr | 2224 | 1.0649 | 0.9619 | 0.2050 | 0.2106 | 2 | |
| AZ-628 | LOXIMVI | 1.0000 | uM | 72 | hr | 1994 | 0.9432 | 0.9619 | 0.2146 | 0.2106 | 3 | |
| AZ-628 | LOXIMVI | 1.0000 | uM | 72 | hr | 1921 | 0.8999 | 0.9619 | 0.2223 | 0.2106 | 4 | |
| AZ-628 | LOXIMVI | 3.1600 | uM | 24 | hr | 2368 | 160 | 0.9017 | 0.8223 | 0.0676 | 0.0554 | 1 |
| AZ-628 | LOXIMVI | 3.1600 | uM | 24 | hr | 2431 | 136 | 0.9372 | 0.8223 | 0.0559 | 0.0554 | 2 |
| AZ-628 | LOXIMVI | 3.1600 | uM | 24 | hr | 1888 | 92 | 0.7334 | 0.8223 | 0.0487 | 0.0554 | 3 |
| AZ-628 | LOXIMVI | 3.1600 | uM | 24 | hr | 1847 | 91 | 0.7171 | 0.8223 | 0.0493 | 0.0554 | 4 |
| AZ-628 | LOXIMVI | 3.1600 | uM | 48 | hr | 2009 | 1.1362 | 1.1612 | 0.1588 | 0.1630 | 1 | |
| AZ-628 | LOXIMVI | 3.1600 | uM | 48 | hr | 1953 | 1.0871 | 1.1612 | 0.1720 | 0.1630 | 2 | |
| AZ-628 | LOXIMVI | 3.1600 | uM | 48 | hr | 2188 | 1.2297 | 1.1612 | 0.1641 | 0.1630 | 3 | |
| AZ-628 | LOXIMVI | 3.1600 | uM | 48 | hr | 2103 | 1.1920 | 1.1612 | 0.1569 | 0.1630 | 4 | |
| AZ-628 | LOXIMVI | 3.1600 | uM | 72 | hr | 1718 | 0.5367 | 0.5120 | 0.4814 | 0.4975 | 1 | |
| AZ-628 | LOXIMVI | 3.1600 | uM | 72 | hr | 1515 | 0.5132 | 0.5120 | 0.4376 | 0.4975 | 2 | |
| AZ-628 | LOXIMVI | 3.1600 | uM | 72 | hr | 1893 | 0.5246 | 0.5120 | 0.5399 | 0.4975 | 3 | |
| AZ-628 | LOXIMVI | 3.1600 | uM | 72 | hr | 1676 | 0.4734 | 0.5120 | 0.5310 | 0.4975 | 4 | |
| Selumetinib | LOXIMVI | 0.0032 | uM | 24 | hr | 2560 | 115 | 0.9984 | 0.9373 | 0.0449 | 0.0508 | 1 |
| Selumetinib | LOXIMVI | 0.0032 | uM | 24 | hr | 2637 | 110 | 1.0319 | 0.9373 | 0.0417 | 0.0508 | 2 |
| Selumetinib | LOXIMVI | 0.0032 | uM | 24 | hr | 2140 | 129 | 0.8212 | 0.9373 | 0.0603 | 0.0508 | 3 |