Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)
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| Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction | Replicate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AZ-628 | MZ7-mel | 3.1600 | uM | 48 | hr | 1441 | 93 | 0.4173 | 0.4646 | 0.0645 | 0.0749 | 4 |
| AZ-628 | MZ7-mel | 3.1600 | uM | 72 | hr | 993 | 281 | 0.2966 | 0.3266 | 0.2830 | 0.2930 | 1 |
| AZ-628 | MZ7-mel | 3.1600 | uM | 72 | hr | 989 | 294 | 0.2895 | 0.3266 | 0.2973 | 0.2930 | 2 |
| AZ-628 | MZ7-mel | 3.1600 | uM | 72 | hr | 1216 | 345 | 0.3628 | 0.3266 | 0.2837 | 0.2930 | 3 |
| AZ-628 | MZ7-mel | 3.1600 | uM | 72 | hr | 1240 | 382 | 0.3574 | 0.3266 | 0.3081 | 0.2930 | 4 |
| Selumetinib | MZ7-mel | 0.0032 | uM | 24 | hr | 1511 | 12 | 1.1356 | 1.0295 | 0.0079 | 0.0105 | 1 |
| Selumetinib | MZ7-mel | 0.0032 | uM | 24 | hr | 1434 | 12 | 1.0773 | 1.0295 | 0.0084 | 0.0105 | 2 |
| Selumetinib | MZ7-mel | 0.0032 | uM | 24 | hr | 1137 | 13 | 0.8515 | 1.0295 | 0.0114 | 0.0105 | 3 |
| Selumetinib | MZ7-mel | 0.0032 | uM | 24 | hr | 1411 | 20 | 1.0538 | 1.0295 | 0.0142 | 0.0105 | 4 |
| Selumetinib | MZ7-mel | 0.0032 | uM | 48 | hr | 2797 | 46 | 0.8517 | 1.0113 | 0.0164 | 0.0200 | 1 |
| Selumetinib | MZ7-mel | 0.0032 | uM | 48 | hr | 3328 | 83 | 1.0046 | 1.0113 | 0.0249 | 0.0200 | 2 |
| Selumetinib | MZ7-mel | 0.0032 | uM | 48 | hr | 3632 | 76 | 1.1009 | 1.0113 | 0.0209 | 0.0200 | 3 |
| Selumetinib | MZ7-mel | 0.0032 | uM | 48 | hr | 3578 | 64 | 1.0879 | 1.0113 | 0.0179 | 0.0200 | 4 |
| Selumetinib | MZ7-mel | 0.0032 | uM | 72 | hr | 2353 | 42 | 0.9627 | 1.1401 | 0.0179 | 0.0201 | 1 |
| Selumetinib | MZ7-mel | 0.0032 | uM | 72 | hr | 3425 | 51 | 1.4054 | 1.1401 | 0.0149 | 0.0201 | 2 |
| Selumetinib | MZ7-mel | 0.0032 | uM | 72 | hr | 2780 | 70 | 1.1289 | 1.1401 | 0.0252 | 0.0201 | 3 |
| Selumetinib | MZ7-mel | 0.0032 | uM | 72 | hr | 2612 | 59 | 1.0635 | 1.1401 | 0.0226 | 0.0201 | 4 |
| Selumetinib | MZ7-mel | 0.0100 | uM | 24 | hr | 1667 | 30 | 1.2402 | 1.1333 | 0.0180 | 0.0133 | 1 |
| Selumetinib | MZ7-mel | 0.0100 | uM | 24 | hr | 1625 | 30 | 1.2083 | 1.1333 | 0.0185 | 0.0133 | 2 |
| Selumetinib | MZ7-mel | 0.0100 | uM | 24 | hr | 1345 | 12 | 1.0098 | 1.1333 | 0.0089 | 0.0133 | 3 |
| Selumetinib | MZ7-mel | 0.0100 | uM | 24 | hr | 1430 | 11 | 1.0750 | 1.1333 | 0.0077 | 0.0133 | 4 |
| Selumetinib | MZ7-mel | 0.0100 | uM | 48 | hr | 2921 | 21 | 0.8978 | 1.0123 | 0.0072 | 0.0157 | 1 |
| Selumetinib | MZ7-mel | 0.0100 | uM | 48 | hr | 3164 | 27 | 0.9712 | 1.0123 | 0.0085 | 0.0157 | 2 |
| Selumetinib | MZ7-mel | 0.0100 | uM | 48 | hr | 3599 | 105 | 1.0817 | 1.0123 | 0.0292 | 0.0157 | 3 |
| Selumetinib | MZ7-mel | 0.0100 | uM | 48 | hr | 3612 | 64 | 1.0984 | 1.0123 | 0.0177 | 0.0157 | 4 |