Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)
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| Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction | Replicate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selumetinib | LOXIMVI | 0.0032 | uM | 24 | hr | 2329 | 131 | 0.8976 | 0.9373 | 0.0562 | 0.0508 | 4 |
| Selumetinib | LOXIMVI | 0.0032 | uM | 48 | hr | 1119 | 0.6595 | 0.8826 | 0.1233 | 0.1112 | 1 | |
| Selumetinib | LOXIMVI | 0.0032 | uM | 48 | hr | 1534 | 0.9190 | 0.8826 | 0.1089 | 0.1112 | 2 | |
| Selumetinib | LOXIMVI | 0.0032 | uM | 48 | hr | 1496 | 0.9197 | 0.8826 | 0.0856 | 0.1112 | 3 | |
| Selumetinib | LOXIMVI | 0.0032 | uM | 48 | hr | 1758 | 1.0320 | 0.8826 | 0.1269 | 0.1112 | 4 | |
| Selumetinib | LOXIMVI | 0.0032 | uM | 72 | hr | 2165 | 1.0432 | 1.3868 | 0.2000 | 0.1607 | 1 | |
| Selumetinib | LOXIMVI | 0.0032 | uM | 72 | hr | 2532 | 1.2348 | 1.3868 | 0.1904 | 0.1607 | 2 | |
| Selumetinib | LOXIMVI | 0.0032 | uM | 72 | hr | 2726 | 1.4359 | 1.3868 | 0.1255 | 0.1607 | 3 | |
| Selumetinib | LOXIMVI | 0.0032 | uM | 72 | hr | 3486 | 1.8335 | 1.3868 | 0.1268 | 0.1607 | 4 | |
| Selumetinib | LOXIMVI | 0.0100 | uM | 24 | hr | 2865 | 136 | 1.1144 | 0.9756 | 0.0475 | 0.0393 | 1 |
| Selumetinib | LOXIMVI | 0.0100 | uM | 24 | hr | 2992 | 148 | 1.1614 | 0.9756 | 0.0495 | 0.0393 | 2 |
| Selumetinib | LOXIMVI | 0.0100 | uM | 24 | hr | 1847 | 57 | 0.7310 | 0.9756 | 0.0309 | 0.0393 | 3 |
| Selumetinib | LOXIMVI | 0.0100 | uM | 24 | hr | 2259 | 66 | 0.8955 | 0.9756 | 0.0292 | 0.0393 | 4 |
| Selumetinib | LOXIMVI | 0.0100 | uM | 48 | hr | 1596 | 0.9701 | 1.2697 | 0.0959 | 0.0778 | 1 | |
| Selumetinib | LOXIMVI | 0.0100 | uM | 48 | hr | 2622 | 1.6445 | 1.2697 | 0.0671 | 0.0778 | 2 | |
| Selumetinib | LOXIMVI | 0.0100 | uM | 48 | hr | 1552 | 0.9587 | 1.2697 | 0.0812 | 0.0778 | 3 | |
| Selumetinib | LOXIMVI | 0.0100 | uM | 48 | hr | 2400 | 1.5053 | 1.2697 | 0.0671 | 0.0778 | 4 | |
| Selumetinib | LOXIMVI | 0.0100 | uM | 72 | hr | 2321 | 1.2853 | 1.9337 | 0.0806 | 0.0676 | 1 | |
| Selumetinib | LOXIMVI | 0.0100 | uM | 72 | hr | 4046 | 2.3207 | 1.9337 | 0.0477 | 0.0676 | 2 | |
| Selumetinib | LOXIMVI | 0.0100 | uM | 72 | hr | 2764 | 1.5552 | 1.9337 | 0.0658 | 0.0676 | 3 | |
| Selumetinib | LOXIMVI | 0.0100 | uM | 72 | hr | 4625 | 2.5737 | 1.9337 | 0.0761 | 0.0676 | 4 | |
| Selumetinib | LOXIMVI | 0.0316 | uM | 24 | hr | 2739 | 98 | 1.0785 | 1.0215 | 0.0358 | 0.0293 | 1 |
| Selumetinib | LOXIMVI | 0.0316 | uM | 24 | hr | 2904 | 93 | 1.1479 | 1.0215 | 0.0320 | 0.0293 | 2 |
| Selumetinib | LOXIMVI | 0.0316 | uM | 24 | hr | 2396 | 49 | 0.9584 | 1.0215 | 0.0205 | 0.0293 | 3 |
| Selumetinib | LOXIMVI | 0.0316 | uM | 24 | hr | 2273 | 66 | 0.9013 | 1.0215 | 0.0290 | 0.0293 | 4 |