Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)
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| Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction | Replicate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AZ-628 | WM-115 | 1.0000 | uM | 72 | hr | 1529 | 825 | 0.2322 | 0.1723 | 0.5396 | 0.6442 | 3 |
| AZ-628 | WM-115 | 1.0000 | uM | 72 | hr | 1531 | 926 | 0.1996 | 0.1723 | 0.6048 | 0.6442 | 4 |
| AZ-628 | WM-115 | 3.1600 | uM | 24 | hr | 446 | 130 | 0.6035 | 0.9459 | 0.2915 | 0.2024 | 1 |
| AZ-628 | WM-115 | 3.1600 | uM | 24 | hr | 571 | 164 | 0.7773 | 0.9459 | 0.2872 | 0.2024 | 2 |
| AZ-628 | WM-115 | 3.1600 | uM | 24 | hr | 678 | 81 | 1.1402 | 0.9459 | 0.1195 | 0.2024 | 3 |
| AZ-628 | WM-115 | 3.1600 | uM | 24 | hr | 744 | 83 | 1.2624 | 0.9459 | 0.1116 | 0.2024 | 4 |
| AZ-628 | WM-115 | 3.1600 | uM | 48 | hr | 372 | 121 | 0.5067 | 0.4240 | 0.3253 | 0.3788 | 1 |
| AZ-628 | WM-115 | 3.1600 | uM | 48 | hr | 365 | 133 | 0.4684 | 0.4240 | 0.3644 | 0.3788 | 2 |
| AZ-628 | WM-115 | 3.1600 | uM | 48 | hr | 277 | 111 | 0.3351 | 0.4240 | 0.4007 | 0.3788 | 3 |
| AZ-628 | WM-115 | 3.1600 | uM | 48 | hr | 332 | 141 | 0.3856 | 0.4240 | 0.4247 | 0.3788 | 4 |
| AZ-628 | WM-115 | 3.1600 | uM | 72 | hr | 1146 | 960 | 0.0614 | 0.0874 | 0.8377 | 0.8202 | 1 |
| AZ-628 | WM-115 | 3.1600 | uM | 72 | hr | 1543 | 1340 | 0.0670 | 0.0874 | 0.8684 | 0.8202 | 2 |
| AZ-628 | WM-115 | 3.1600 | uM | 72 | hr | 1520 | 1204 | 0.1042 | 0.0874 | 0.7921 | 0.8202 | 3 |
| AZ-628 | WM-115 | 3.1600 | uM | 72 | hr | 1633 | 1278 | 0.1171 | 0.0874 | 0.7826 | 0.8202 | 4 |
| Selumetinib | WM-115 | 0.0032 | uM | 24 | hr | 638 | 43 | 1.1364 | 1.0647 | 0.0674 | 0.0496 | 1 |
| Selumetinib | WM-115 | 0.0032 | uM | 24 | hr | 530 | 20 | 0.9740 | 1.0647 | 0.0377 | 0.0496 | 2 |
| Selumetinib | WM-115 | 0.0032 | uM | 24 | hr | 599 | 25 | 1.0963 | 1.0647 | 0.0417 | 0.0496 | 3 |
| Selumetinib | WM-115 | 0.0032 | uM | 24 | hr | 581 | 30 | 1.0523 | 1.0647 | 0.0516 | 0.0496 | 4 |
| Selumetinib | WM-115 | 0.0032 | uM | 48 | hr | 802 | 23 | 1.5727 | 1.0175 | 0.0287 | 0.0459 | 1 |
| Selumetinib | WM-115 | 0.0032 | uM | 48 | hr | 690 | 30 | 1.3325 | 1.0175 | 0.0435 | 0.0459 | 2 |
| Selumetinib | WM-115 | 0.0032 | uM | 48 | hr | 307 | 17 | 0.5855 | 1.0175 | 0.0554 | 0.0459 | 3 |
| Selumetinib | WM-115 | 0.0032 | uM | 48 | hr | 304 | 17 | 0.5794 | 1.0175 | 0.0559 | 0.0459 | 4 |
| Selumetinib | WM-115 | 0.0032 | uM | 72 | hr | 3147 | 100 | 1.0051 | 1.0349 | 0.0318 | 0.0278 | 1 |
| Selumetinib | WM-115 | 0.0032 | uM | 72 | hr | 3316 | 70 | 1.0707 | 1.0349 | 0.0211 | 0.0278 | 2 |
| Selumetinib | WM-115 | 0.0032 | uM | 72 | hr | 3102 | 95 | 0.9919 | 1.0349 | 0.0306 | 0.0278 | 3 |