Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)
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| Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction | Replicate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Selumetinib | COLO 858 | 0.1000 | uM | 72 | hr | 1509 | 112 | 0.5074 | 0.5449 | 0.0742 | 0.0769 | 1 |
| Selumetinib | COLO 858 | 0.1000 | uM | 72 | hr | 1744 | 114 | 0.5921 | 0.5449 | 0.0654 | 0.0769 | 2 |
| Selumetinib | COLO 858 | 0.1000 | uM | 72 | hr | 1382 | 128 | 0.4555 | 0.5449 | 0.0926 | 0.0769 | 3 |
| Selumetinib | COLO 858 | 0.1000 | uM | 72 | hr | 1859 | 140 | 0.6244 | 0.5449 | 0.0753 | 0.0769 | 4 |
| Selumetinib | COLO 858 | 0.3160 | uM | 24 | hr | 4059 | 319 | 1.2493 | 1.0085 | 0.0786 | 0.0830 | 1 |
| Selumetinib | COLO 858 | 0.3160 | uM | 24 | hr | 4087 | 312 | 1.2610 | 1.0085 | 0.0763 | 0.0830 | 2 |
| Selumetinib | COLO 858 | 0.3160 | uM | 24 | hr | 2263 | 203 | 0.6881 | 1.0085 | 0.0897 | 0.0830 | 3 |
| Selumetinib | COLO 858 | 0.3160 | uM | 24 | hr | 2742 | 240 | 0.8358 | 1.0085 | 0.0875 | 0.0830 | 4 |
| Selumetinib | COLO 858 | 0.3160 | uM | 48 | hr | 2361 | 363 | 0.4565 | 0.4546 | 0.1538 | 0.1547 | 1 |
| Selumetinib | COLO 858 | 0.3160 | uM | 48 | hr | 2287 | 366 | 0.4389 | 0.4546 | 0.1600 | 0.1547 | 2 |
| Selumetinib | COLO 858 | 0.3160 | uM | 48 | hr | 2403 | 366 | 0.4654 | 0.4546 | 0.1523 | 0.1547 | 3 |
| Selumetinib | COLO 858 | 0.3160 | uM | 48 | hr | 2363 | 361 | 0.4574 | 0.4546 | 0.1528 | 0.1547 | 4 |
| Selumetinib | COLO 858 | 0.3160 | uM | 72 | hr | 1217 | 157 | 0.3850 | 0.4268 | 0.1290 | 0.1341 | 1 |
| Selumetinib | COLO 858 | 0.3160 | uM | 72 | hr | 1382 | 175 | 0.4384 | 0.4268 | 0.1266 | 0.1341 | 2 |
| Selumetinib | COLO 858 | 0.3160 | uM | 72 | hr | 1228 | 209 | 0.3701 | 0.4268 | 0.1702 | 0.1341 | 3 |
| Selumetinib | COLO 858 | 0.3160 | uM | 72 | hr | 1590 | 176 | 0.5136 | 0.4268 | 0.1107 | 0.1341 | 4 |
| Selumetinib | COLO 858 | 1.0000 | uM | 24 | hr | 3878 | 512 | 1.1244 | 0.9366 | 0.1320 | 0.1371 | 1 |
| Selumetinib | COLO 858 | 1.0000 | uM | 24 | hr | 4067 | 545 | 1.1765 | 0.9366 | 0.1340 | 0.1371 | 2 |
| Selumetinib | COLO 858 | 1.0000 | uM | 24 | hr | 2444 | 315 | 0.7112 | 0.9366 | 0.1289 | 0.1371 | 3 |
| Selumetinib | COLO 858 | 1.0000 | uM | 24 | hr | 2596 | 398 | 0.7342 | 0.9366 | 0.1533 | 0.1371 | 4 |
| Selumetinib | COLO 858 | 1.0000 | uM | 48 | hr | 2054 | 398 | 0.3784 | 0.3740 | 0.1938 | 0.2319 | 1 |
| Selumetinib | COLO 858 | 1.0000 | uM | 48 | hr | 1935 | 372 | 0.3571 | 0.3740 | 0.1923 | 0.2319 | 2 |
| Selumetinib | COLO 858 | 1.0000 | uM | 48 | hr | 2243 | 619 | 0.3711 | 0.3740 | 0.2760 | 0.2319 | 3 |
| Selumetinib | COLO 858 | 1.0000 | uM | 48 | hr | 2321 | 616 | 0.3896 | 0.3740 | 0.2654 | 0.2319 | 4 |
| Selumetinib | COLO 858 | 1.0000 | uM | 72 | hr | 1235 | 331 | 0.3284 | 0.3419 | 0.2680 | 0.2586 | 1 |