PCI-32765 KiNativ -- single dose experiment - Dataset (ID:20206)
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| Small Molecule | Cell Line | Protein | Sequence | Labeling Site | % Inhibition | Assay compound conc | Conc unit |
|---|---|---|---|---|---|---|---|
| Ibrutinib | Ramos (RA 1) | PIK3CD | VNWLAHNVSKDNRQ | ATP | -50.9 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | PIP4K2A | AKELPTLKDNDFINEGQK | ATP | 0.2 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | PI42C | TLVIKEVSSEDIADMHSNLSNYHQYIVK | ATP | -87.5 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | FYV1 | GGKSGAAFYATEDDRFILK | ATP | -1.5 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | PITSLRE | DLKTSNLLLSHAGILK | Lys2 | 7.1 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | PKD1,PKD2 | NIVHCDLKPENVLLASADPFPQVK | Lys2 | 12.3 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | PKD2 | DVAVKVIDK | Lys1 | 13.2 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | PKD3 | NIVHCDLKPENVLLASAEPFPQVK | Lys2 | -34.5 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | PKN1 | VLLSEFRPSGELFAIKALK | Lys1 | 7.6 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | PKR | DLKPSNIFLVDTK | Lys2 | 4.0 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | PLK1 | CFEISDADTKEVFAGKIVPK | Lys1 | 21.1 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | FAK2 | YIEDEDYYKASVTR | Activation Loop | -12.2 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | ROCK1,ROCK2 | DVKPDNMLLDK | Lys2 | -59.2 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | RSK1 domain1 | DLKPENILLDEEGHIKLTDFGLSKEAIDHEK | Lys2 | -36.9 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | RSK1_domain2 | DLKPSNILYVDESGNPECLR | Lys2 | -3.5 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | RSK2_domain2 | DLKPSNILYVDESGNPESIR | Lys2 | 14.1 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | SGK3 | FYAVKVLQK | Lys1 | 5.5 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | SLK | DLKAGNILFTLDGDIK | Lys2 | -4.1 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | STLK5 | YSVKVLPWLSPEVLQQNLQGYDAK | Activation Loop | -14.7 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | STLK6 | SIKASHILISGDGLVTLSGLSHLHSLVK | Lys2 | 16.4 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | SYK | ISDFGLSKALR | Activation Loop | 3.3 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | SYK | TVAVKILK | Lys1 | 12.4 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | TAO1,TAOK3 | DIKAGNILLTEPGQVK | Lys2 | -15.4 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | TAOK2 | DVKAGNILLSEPGLVK | Lys2 | -19.1 | 1 | uM |
| Ibrutinib | Ramos (RA 1) | TEC | YVLDDQYTSSSGAKFPVK | Activation Loop | >90 | 1 | uM |