HMS LINCS Project

Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)

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Small molecules	Cells
10057:MK2206 10098:Gefitinib 10172:GSK1059615 10232:Dactolisib 10280:Triciribine 10345:Torkinib	50091:AU565 50213:HCC1954 50541:T47D 50583:MCF 10A

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Small Molecule	Cell Line	Drug Concentration	Conc Units	Timepoint	Timepoint Units	Measured pERK (Alexa 488)	Measured p-Rb (Alexa 568)	Alexa Fluor 647	Measured p-Akt/p-4EBP1/p-S6 (Alexa 647)	Image
Triciribine	HCC1954	100.0	nM	6	hr	264.27	86.96	p-Akt	36.18
Triciribine	HCC1954	100.0	nM	24	hr	258.77	99.98	p-Akt	36.63
Dactolisib	HCC1954	100.0	nM	6	hr	173.90	40.33	p-Akt	15.09
Dactolisib	HCC1954	100.0	nM	24	hr	266.80	76.28	p-Akt	22.00
Gefitinib	MCF 10A	100.0	nM	6	hr	355.82	167.25	p-Akt	37.59
Gefitinib	MCF 10A	100.0	nM	24	hr	326.57	166.48	p-Akt	33.50
Torkinib	MCF 10A	31.6	nM	6	hr	486.89	163.76	p-Akt	30.21
Torkinib	MCF 10A	31.6	nM	24	hr	419.53	153.85	p-Akt	24.13
GSK1059615	MCF 10A	100.0	nM	6	hr	347.86	165.88	p-Akt	27.61
GSK1059615	MCF 10A	100.0	nM	24	hr	277.04	142.43	p-Akt	20.80
MK2206	MCF 10A	100.0	nM	6	hr	373.61	148.49	p-Akt	24.10
MK2206	MCF 10A	100.0	nM	24	hr	274.43	146.05	p-Akt	20.16
Triciribine	MCF 10A	100.0	nM	6	hr	376.35	149.47	p-Akt	24.23
Triciribine	MCF 10A	100.0	nM	24	hr	251.10	142.37	p-Akt	17.85
Dactolisib	MCF 10A	100.0	nM	6	hr	366.31	125.98	p-Akt	21.89
Dactolisib	MCF 10A	100.0	nM	24	hr	312.16	90.13	p-Akt	16.35
Gefitinib	T47D	100.0	nM	6	hr	158.04	90.93	p-Akt	93.71
Gefitinib	T47D	100.0	nM	24	hr	150.12	101.21	p-Akt	72.97
Torkinib	T47D	31.6	nM	6	hr	162.54	75.76	p-Akt	31.83
Torkinib	T47D	31.6	nM	24	hr	127.17	45.02	p-Akt	24.28
GSK1059615	T47D	100.0	nM	6	hr	170.60	81.49	p-Akt	64.01
GSK1059615	T47D	100.0	nM	24	hr	153.22	70.14	p-Akt	38.11
MK2206	T47D	100.0	nM	6	hr	97.74	36.32	p-Akt	6.68
MK2206	T47D	100.0	nM	24	hr	141.16	71.21	p-Akt	19.39
Triciribine	T47D	100.0	nM	6	hr	111.67	49.88	p-Akt	12.75

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