Breast cell line dose response to target inhibition measured by high throughput microscopy - Dataset (ID:20136)
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| Small Molecule | Cell Line | Drug Concentration | Conc Units | Timepoint | Timepoint Units | Measured pERK (Alexa 488) | Measured p-Rb (Alexa 568) | Alexa Fluor 647 | Measured p-Akt/p-4EBP1/p-S6 (Alexa 647) | Image |
|---|---|---|---|---|---|---|---|---|---|---|
| Triciribine | HCC1954 | 3.16 | uM | 24 | hr | 234.21 | 102.27 | p-4EBP1 | 112.92 | |
| Dactolisib | HCC1954 | 3.16 | uM | 6 | hr | 257.41 | 72.20 | p-4EBP1 | 10.80 | |
| Dactolisib | HCC1954 | 3.16 | uM | 24 | hr | 254.30 | 67.56 | p-4EBP1 | 11.95 | |
| Gefitinib | MCF 10A | 3.16 | uM | 6 | hr | 190.65 | 138.05 | p-4EBP1 | 289.73 | |
| Gefitinib | MCF 10A | 3.16 | uM | 24 | hr | 178.17 | 26.30 | p-4EBP1 | 151.62 | |
| Torkinib | MCF 10A | 2.37 | uM | 6 | hr | 630.91 | 159.45 | p-4EBP1 | 13.63 | |
| Torkinib | MCF 10A | 2.37 | uM | 24 | hr | 444.83 | 69.44 | p-4EBP1 | 13.97 | |
| GSK1059615 | MCF 10A | 3.16 | uM | 6 | hr | 228.04 | 116.81 | p-4EBP1 | 25.33 | |
| GSK1059615 | MCF 10A | 3.16 | uM | 24 | hr | 222.26 | 118.70 | p-4EBP1 | 18.15 | |
| MK2206 | MCF 10A | 3.16 | uM | 6 | hr | 382.94 | 145.75 | p-4EBP1 | 355.15 | |
| MK2206 | MCF 10A | 3.16 | uM | 24 | hr | 349.85 | 162.04 | p-4EBP1 | 185.70 | |
| Triciribine | MCF 10A | 3.16 | uM | 6 | hr | 386.38 | 146.88 | p-4EBP1 | 356.04 | |
| Triciribine | MCF 10A | 3.16 | uM | 24 | hr | 296.83 | 137.36 | p-4EBP1 | 196.53 | |
| Dactolisib | MCF 10A | 3.16 | uM | 6 | hr | 309.38 | 126.66 | p-4EBP1 | 5.36 | |
| Dactolisib | MCF 10A | 3.16 | uM | 24 | hr | 377.20 | 83.95 | p-4EBP1 | 15.09 | |
| Gefitinib | T47D | 3.16 | uM | 6 | hr | 158.85 | 91.69 | p-4EBP1 | 454.76 | |
| Gefitinib | T47D | 3.16 | uM | 24 | hr | 137.19 | 93.74 | p-4EBP1 | 367.13 | |
| Torkinib | T47D | 2.37 | uM | 6 | hr | 146.35 | 68.42 | p-4EBP1 | 22.59 | |
| Torkinib | T47D | 2.37 | uM | 24 | hr | 125.67 | 44.17 | p-4EBP1 | 13.31 | |
| GSK1059615 | T47D | 3.16 | uM | 6 | hr | 160.82 | 57.36 | p-4EBP1 | 164.67 | |
| GSK1059615 | T47D | 3.16 | uM | 24 | hr | 205.03 | 68.86 | p-4EBP1 | 186.45 | |
| MK2206 | T47D | 3.16 | uM | 6 | hr | 105.26 | 37.76 | p-4EBP1 | 91.36 | |
| MK2206 | T47D | 3.16 | uM | 24 | hr | 140.41 | 48.59 | p-4EBP1 | 276.48 | |
| Triciribine | T47D | 3.16 | uM | 6 | hr | 95.94 | 25.51 | p-4EBP1 | 82.61 | |
| Triciribine | T47D | 3.16 | uM | 24 | hr | 159.89 | 75.75 | p-4EBP1 | 337.52 | |