Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK923295 | MCF 10F | -4.4776 | 0.8219 | -6.1677 | -4.7707 | -6.3486 | 1.1462 | 0.2546 | 0.4445 | 6.9424 |
| GSK923295 | SUM1315MO2 | -4.4776 | 0.9754 | -7.6036 | -7.0706 | -7.6782 | 2.7190 | 0.4822 | 0.4822 | 6.3987 |
| GSK923295 | SUM149PT | -4.4776 | 0.8496 | -7.2931 | -7.0064 | -7.1666 | 2.5450 | 0.3641 | 0.3644 | 6.1112 |
| GSK923295 | SUM159PT | -4.4776 | 0.8759 | -7.4856 | -7.4327 | -7.4703 | 3.2010 | 0.1772 | 0.1772 | 5.4892 |
| GSK923295 | SUM185PE | -4.4776 | 0.7315 | -4.9198 | -4.9198 | -5.4984 | 1.6835 | 0.0000 | 0.1662 | 7.6372 |
| GSK923295 | SUM225CWN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| GSK923295 | SUM229PE | -4.4776 | 0.9068 | -7.4356 | -7.2571 | -7.4635 | 2.0060 | 0.2806 | 0.2806 | 5.6185 |
| GSK923295 | SUM52PE | -4.4776 | 0.9727 | -7.6256 | -7.5380 | -7.6586 | 3.9030 | 0.2728 | 0.2728 | 5.4051 |
| GSK923295 | 184A1 | -4.4776 | 0.9535 | -4.7688 | -4.7687 | -4.9643 | 2.7460 | 0.0000 | 0.1369 | 7.9383 |
| GSK923295 | MCF12A | -4.4776 | 0.7869 | -5.5316 | -5.5319 | -5.8695 | 0.4446 | 0.0000 | 0.2536 | 6.7154 |
| GSK923295 | MX1 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| GSK923295 | T47DKBLUC | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| GSK923295 | 600MPE | -4.4776 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.5754 |
| GSK923295 | HCC2185 | -4.4776 | 0.9320 | -7.0646 | -4.4776 | -7.1458 | 3.9970 | 0.5961 | 0.5961 | 7.3696 |
| GSK923295 | HCC3153 | -4.4776 | 0.9870 | -7.1431 | -6.9427 | -7.1724 | 3.5760 | 0.3647 | 0.3647 | 6.2363 |
| GSK923295 | LY2 | -4.4776 | 0.8034 | -4.9284 | -4.9283 | NaN | 0.3424 | 0.0000 | 0.4121 | 7.1979 |
| GSK923295 | ZR75B | -4.4776 | 0.8762 | -7.3096 | -4.4776 | -7.1902 | 1.8160 | 0.5903 | 0.5903 | 7.1801 |
| Ibandronate | MCF7 | -2.8239 | 0.9560 | -4.0749 | -3.9651 | -4.2942 | 2.3740 | 0.2259 | 0.2267 | 7.3417 |
| Ibandronate | SK-BR-3 | -2.8239 | 0.8790 | -4.0489 | -3.1300 | -4.0539 | 0.6192 | 0.3651 | 0.4594 | 7.3861 |
| Ibandronate | MDA-MB-231 | -2.8239 | 0.8274 | -4.2119 | -4.1976 | -4.3202 | 1.0440 | 0.0172 | 0.0509 | 7.4866 |
| Ibandronate | AU565 | -2.8239 | 0.8971 | -3.9079 | -3.3364 | -3.8002 | 1.5560 | 0.4354 | 0.4468 | 7.8463 |
| Ibandronate | BT-20 | -2.8239 | 0.9169 | -4.1859 | -4.1420 | -4.7408 | 0.9216 | 0.0499 | 0.1140 | 6.5621 |
| Ibandronate | BT-474 | -2.8239 | 0.7426 | -4.0049 | -2.8239 | -4.0309 | 2.1170 | 0.5619 | 0.5633 | 7.9947 |
| Ibandronate | BT-483 | -2.8239 | 0.9103 | -3.9639 | -2.9175 | -4.2689 | 1.2730 | 0.4781 | 0.4973 | 7.8218 |
| Ibandronate | BT-549 | -2.8239 | 0.9543 | -4.4919 | -4.4223 | -4.5571 | 0.9217 | 0.0690 | 0.0952 | 6.3357 |