Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| CGC-11144 | SUM225CWN | -3.1500 | 0.9366 | -4.5560 | -4.5560 | -5.4441 | 0.6074 | 0.0000 | 0.1231 | 6.4315 |
| CGC-11144 | SUM229PE | -3.1500 | 0.9824 | -5.7940 | -5.7935 | -6.2524 | 0.8376 | 0.0000 | 0.0069 | 4.6658 |
| CGC-11144 | SUM52PE | -3.1500 | 0.9702 | -6.6460 | -6.6393 | -6.8275 | 2.7340 | 0.0144 | 0.0144 | 3.5998 |
| CGC-11144 | 184A1 | -3.1500 | 0.9716 | -6.1570 | -6.1300 | -6.3620 | 2.4415 | 0.0984 | 0.1035 | 4.7721 |
| CGC-11144 | MCF12A | -3.1500 | 0.9901 | -6.0770 | -6.0770 | -6.2451 | 0.7874 | 0.0000 | 0.0049 | 4.2375 |
| CGC-11144 | MX1 | -3.1500 | 0.9973 | -5.8730 | -5.8689 | -6.5353 | 0.8389 | 0.0040 | 0.0092 | 4.6340 |
| CGC-11144 | T47DKBLUC | -3.1500 | 0.9913 | -6.4130 | -6.4110 | -6.5411 | 3.5590 | 0.0094 | 0.0094 | 3.7715 |
| CGC-11144 | 600MPE | -3.1500 | 0.9957 | -6.2260 | -6.2127 | -6.5452 | 1.9090 | 0.0284 | 0.0284 | 4.1999 |
| CGC-11144 | HCC2185 | -3.1500 | 0.9864 | -6.1125 | -6.0965 | -6.6935 | 1.3635 | 0.0238 | 0.0240 | 4.5099 |
| CGC-11144 | HCC3153 | -3.1500 | 0.9913 | -6.6440 | -6.6419 | -6.7766 | 3.9840 | 0.0111 | 0.0111 | 3.7081 |
| CGC-11144 | LY2 | -3.1500 | 0.9381 | -4.9920 | -4.9848 | -5.2261 | 1.3690 | 0.0111 | 0.0141 | 6.4067 |
| CGC-11144 | ZR75B | -3.1500 | 0.9706 | -6.0550 | -6.0199 | -6.4000 | 0.6782 | 0.0265 | 0.0368 | 4.5258 |
| Cisplatin | MCF7 | -3.6021 | 0.9694 | -4.3218 | -4.2340 | -4.6447 | 1.1780 | 0.0755 | 0.1981 | 7.6951 |
| Cisplatin | SK-BR-3 | -3.6021 | 0.9761 | -5.4371 | -5.4161 | -5.6548 | 2.0830 | 0.0480 | 0.0482 | 6.2677 |
| Cisplatin | MDA-MB-231 | -3.6021 | 0.9419 | -4.4982 | -4.4918 | -4.5480 | 2.3010 | 0.0287 | 0.0530 | 7.6001 |
| Cisplatin | AU565 | -3.6021 | 0.9765 | -5.6661 | -5.6557 | -5.7959 | 1.8050 | 0.0133 | 0.0138 | 5.6379 |
| Cisplatin | BT-20 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Cisplatin | BT-474 | -3.6021 | 0.9343 | -4.3346 | -4.3212 | -4.5559 | 2.3970 | 0.1746 | 0.1911 | 7.7746 |
| Cisplatin | BT-483 | -3.6021 | 0.9235 | -4.5374 | -4.3339 | -4.8421 | 1.8080 | 0.2855 | 0.2998 | 7.6963 |
| Cisplatin | BT-549 | -3.6021 | 0.9868 | -5.5581 | -5.5576 | -5.6247 | 1.2820 | 0.0000 | 0.0084 | 5.6253 |
| Cisplatin | CAMA-1 | -3.6021 | 0.9651 | -4.1687 | -4.1686 | -4.4034 | 2.3580 | 0.0000 | 0.0441 | 7.6701 |
| Cisplatin | HCC1143 | -3.6021 | 0.9402 | -4.8986 | -4.8948 | -5.1570 | 1.6366 | 0.0099 | 0.0373 | 6.6349 |
| Cisplatin | HCC1395 | -3.6021 | 0.9797 | -5.5491 | -5.5486 | -5.9182 | 1.2220 | 0.0000 | 0.0042 | 5.8920 |
| Cisplatin | HCC1419 | -3.6021 | 0.9325 | -4.5561 | -4.5044 | -4.9086 | 1.3860 | 0.0163 | 0.0938 | 7.5745 |
| Cisplatin | HCC1428 | -3.6021 | 0.9643 | -4.4062 | -4.3978 | -4.5393 | 3.9965 | 0.0367 | 0.0381 | 7.5993 |