Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Bortezomib | HCC3153 | -3.7773 | 0.9917 | -7.0073 | -7.0049 | -7.1651 | 2.4520 | 0.0078 | 0.0078 | 3.9384 |
| Bortezomib | LY2 | -3.7773 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 7.7302 |
| Bortezomib | ZR75B | -3.7773 | 0.9686 | -6.7043 | -6.5523 | -6.8642 | 1.0470 | 0.1531 | 0.1538 | 4.9127 |
| Carboplatin | MCF7 | -2.8697 | 0.9478 | -3.2721 | -3.1874 | -3.6325 | 1.1680 | 0.0173 | 0.3221 | 8.0498 |
| Carboplatin | SK-BR-3 | -2.8697 | 0.9748 | -4.6717 | -4.6515 | -4.9058 | 1.8745 | 0.0377 | 0.0388 | 6.2122 |
| Carboplatin | MDA-MB-231 | -2.8697 | 0.9545 | -3.7952 | -3.7726 | -3.8371 | 2.1935 | 0.0531 | 0.0742 | 7.6689 |
| Carboplatin | AU565 | -2.8697 | 0.9747 | -4.6382 | -4.6380 | -4.9765 | 1.2765 | 0.0000 | 0.0056 | 5.9440 |
| Carboplatin | BT-20 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Carboplatin | BT-474 | -2.8697 | 0.9725 | -3.5755 | -3.5662 | -3.9801 | 2.0330 | 0.0708 | 0.0817 | 7.6582 |
| Carboplatin | BT-483 | -2.8697 | 0.8733 | -4.5517 | -4.0027 | -5.7599 | 0.5318 | 0.2447 | 0.3301 | 6.8846 |
| Carboplatin | BT-549 | -2.8697 | 0.9879 | -4.5777 | -4.5778 | -4.6487 | 1.5895 | 0.0000 | 0.0032 | 6.1380 |
| Carboplatin | CAMA-1 | -2.8697 | 0.9701 | -3.4136 | -3.4136 | -3.7413 | 1.9730 | 0.0000 | 0.0779 | 7.6687 |
| Carboplatin | HCC1143 | -2.8697 | 0.9506 | -3.7960 | -3.7773 | -3.9854 | 2.7660 | 0.0483 | 0.0663 | 7.5528 |
| Carboplatin | HCC1395 | -2.8697 | 0.9769 | -4.4737 | -4.4737 | -4.9821 | 1.1440 | 0.0000 | 0.0157 | 6.2004 |
| Carboplatin | HCC1419 | -2.8697 | 0.9666 | -3.7499 | -3.7116 | -4.1132 | 1.7565 | 0.0744 | 0.0989 | 7.5057 |
| Carboplatin | HCC1428 | -2.8697 | 0.9587 | -3.5815 | -3.5573 | -3.8724 | 1.9390 | 0.0510 | 0.0890 | 7.8261 |
| Carboplatin | HCC1569 | -2.8697 | 0.9152 | -3.8483 | -3.7117 | -3.9916 | 1.0705 | 0.1346 | 0.2082 | 7.3559 |
| Carboplatin | HCC1806 | -2.8697 | 0.9862 | -4.6327 | -4.6326 | -4.8368 | 1.3335 | 0.0000 | 0.0047 | 6.0367 |
| Carboplatin | HCC1937 | -2.8697 | 0.9648 | -4.1867 | -4.1866 | -4.4863 | 1.3400 | 0.0384 | 0.0485 | 6.4961 |
| Carboplatin | HCC1954 | -2.8697 | 0.9528 | -4.1977 | -4.1781 | -4.3885 | 1.5360 | 0.0329 | 0.0416 | 6.4111 |
| Carboplatin | HCC202 | -2.8697 | 0.8745 | -3.9542 | -3.9454 | -4.6154 | 1.4710 | 0.0179 | 0.0624 | 7.0408 |
| Carboplatin | HCC38 | -2.8697 | 0.9573 | -4.5117 | -4.4729 | -4.8234 | 1.6840 | 0.0665 | 0.0686 | 6.4676 |
| Carboplatin | HCC70 | -2.8697 | 0.9948 | -4.7157 | -4.7155 | -4.8423 | 3.9990 | 0.0071 | 0.0071 | 6.0624 |
| Carboplatin | Hs 578T | -2.8697 | 0.9450 | -4.0527 | -4.0529 | -4.1583 | 2.9280 | 0.0005 | 0.0007 | 6.5515 |
| Carboplatin | MB 157 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |