Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| IKK16 | SUM229PE | -4.1759 | 0.9805 | -5.7029 | -5.7033 | -6.0260 | 1.6700 | 0.0000 | 0.0028 | 6.1809 |
| IKK16 | SUM52PE | -4.1759 | 0.8879 | -5.7359 | -5.7363 | -6.0337 | 1.0600 | 0.0000 | 0.0217 | 5.7310 |
| IKK16 | 184A1 | -4.1759 | 0.9647 | -5.7659 | -5.7658 | -6.0556 | 1.2510 | 0.0000 | 0.0102 | 6.4737 |
| IKK16 | MCF12A | -4.1759 | 0.9803 | -5.4249 | -5.4239 | -5.4705 | 3.6660 | 0.0056 | 0.0056 | 6.6153 |
| IKK16 | MX1 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| IKK16 | T47DKBLUC | -4.1759 | 0.9702 | -5.3419 | -5.3403 | -5.4431 | 3.9990 | 0.0068 | 0.0068 | 6.6416 |
| IKK16 | 600MPE | -4.1759 | 0.9757 | -5.2299 | -5.2297 | -5.3825 | 3.6970 | 0.0000 | 0.0001 | 6.7279 |
| IKK16 | HCC2185 | -4.1759 | 0.9620 | -5.1939 | -5.1937 | -5.3778 | 2.4340 | 0.0000 | 0.0033 | 7.0880 |
| IKK16 | HCC3153 | -4.1759 | 0.9550 | -5.3819 | -5.3799 | -5.5158 | 4.0000 | 0.0079 | 0.0079 | 6.8383 |
| IKK16 | LY2 | -4.1759 | 0.9469 | -5.2209 | -5.2210 | -5.2978 | 2.4090 | 0.0000 | 0.0030 | 7.3160 |
| IKK16 | ZR75B | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Lestaurtinib | MCF7 | -4.4776 | 0.9697 | -5.6836 | -5.6794 | -5.8446 | 2.6860 | 0.0134 | 0.0139 | 6.8273 |
| Lestaurtinib | SK-BR-3 | -4.4776 | 0.9345 | -5.4494 | -5.4494 | -5.9986 | 0.7525 | 0.0000 | 0.1566 | 6.9315 |
| Lestaurtinib | MDA-MB-231 | -4.4776 | 0.9168 | -6.0756 | -6.0341 | -6.1536 | 1.1170 | 0.0507 | 0.0660 | 6.3413 |
| Lestaurtinib | AU565 | -4.4776 | 0.9446 | -5.8486 | -5.8491 | -6.1757 | 0.8318 | 0.0000 | 0.0674 | 6.1936 |
| Lestaurtinib | BT-20 | -4.4776 | 0.9456 | -5.2916 | -5.2914 | -5.5599 | 1.5200 | 0.0000 | 0.0548 | 6.9871 |
| Lestaurtinib | BT-474 | -4.4776 | 0.9214 | -5.6966 | -5.6966 | -6.6970 | 0.7403 | 0.0000 | 0.1226 | 6.4193 |
| Lestaurtinib | BT-483 | -4.4776 | 0.8558 | -4.7712 | -4.6098 | -5.9511 | 0.5614 | 0.1917 | 0.5092 | 7.5934 |
| Lestaurtinib | BT-549 | -4.4776 | 0.9229 | -6.1026 | -6.1025 | -6.2071 | 0.6460 | 0.0000 | 0.0819 | 6.0665 |
| Lestaurtinib | CAMA-1 | -4.4776 | 0.8685 | -5.3860 | -5.3862 | -5.9355 | 1.2339 | 0.0000 | 0.0977 | 6.8083 |
| Lestaurtinib | HCC1143 | -4.4776 | 0.9191 | -6.1356 | -6.1354 | -6.5259 | 0.6055 | 0.0000 | 0.0902 | 5.8695 |
| Lestaurtinib | HCC1395 | -4.4776 | 0.9239 | -6.0661 | -6.0657 | -6.9291 | 0.5978 | 0.0000 | 0.1029 | 6.0443 |
| Lestaurtinib | HCC1419 | -4.4776 | 0.8499 | -5.1819 | -5.1820 | -6.2045 | 1.0720 | 0.0000 | 0.1495 | 6.9135 |
| Lestaurtinib | HCC1428 | -4.4776 | 0.9031 | -5.4869 | -5.4869 | -6.4079 | 0.6133 | 0.0000 | 0.1966 | 6.6989 |
| Lestaurtinib | HCC1569 | -4.4776 | 0.9245 | -5.7231 | -5.7214 | -6.2004 | 0.8699 | 0.0018 | 0.0825 | 6.8362 |