Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1059615 | T47D | -3.8761 | 0.9767 | -6.1936 | -6.0514 | -6.9077 | 0.7031 | 0.1031 | 0.1270 | 5.5762 |
| GSK1059615 | UACC-812 | -3.8761 | 0.9593 | -5.9671 | -5.8291 | -6.4559 | 1.3025 | 0.1687 | 0.1703 | 6.2995 |
| GSK1059615 | UACC-893 | -3.8761 | 0.9457 | -6.4781 | -6.4285 | -6.9731 | 1.5100 | 0.0723 | 0.0727 | 5.2500 |
| GSK1059615 | ZR-75-1 | -3.8761 | 0.9687 | -5.6631 | -5.5259 | -5.9889 | 1.0260 | 0.1305 | 0.1531 | 6.5481 |
| GSK1059615 | 184B5 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| GSK1059615 | HCC1187 | -3.8761 | 0.9667 | -5.8266 | -5.8267 | -6.7042 | 0.7908 | 0.0000 | 0.0283 | 5.6757 |
| GSK1059615 | MCF 10A | -3.8761 | 0.9898 | -6.4736 | -6.4606 | -6.6011 | 1.1270 | 0.0213 | 0.0228 | 4.9008 |
| GSK1059615 | MCF 10F | -3.8761 | 0.9758 | -6.5361 | -6.4562 | -6.7332 | 0.9002 | 0.0756 | 0.0794 | 5.1553 |
| GSK1059615 | SUM1315MO2 | -3.8761 | 0.9604 | -5.9386 | -5.8331 | -6.4593 | 1.1460 | 0.1221 | 0.1270 | 5.9782 |
| GSK1059615 | SUM149PT | -3.8761 | 0.9712 | -5.9691 | -5.9579 | -6.0461 | 2.5850 | 0.0364 | 0.0378 | 5.6620 |
| GSK1059615 | SUM159PT | -3.8761 | 0.9804 | -6.6931 | -6.6443 | -6.7490 | 1.4790 | 0.0657 | 0.0659 | 4.7272 |
| GSK1059615 | SUM185PE | -3.8761 | 0.9628 | -6.3681 | -6.2921 | -7.0653 | 0.7818 | 0.0638 | 0.0742 | 5.3114 |
| GSK1059615 | SUM225CWN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| GSK1059615 | SUM229PE | -3.8761 | 0.9551 | -5.9816 | -5.9458 | -6.2709 | 1.3390 | 0.0505 | 0.0549 | 5.6768 |
| GSK1059615 | SUM52PE | -3.8761 | 0.9310 | -6.6981 | -6.5460 | -6.7975 | 1.4890 | 0.2331 | 0.2331 | 5.7665 |
| GSK1059615 | 184A1 | -3.8761 | 0.9610 | -7.3446 | -6.9876 | -7.7542 | 1.1090 | 0.2956 | 0.2957 | 5.1600 |
| GSK1059615 | MCF12A | -3.8761 | 0.9580 | -5.9441 | -5.9254 | -6.3645 | 1.0795 | 0.0238 | 0.0324 | 5.6533 |
| GSK1059615 | MX1 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| GSK1059615 | T47DKBLUC | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| GSK1059615 | 600MPE | -3.8761 | 0.9156 | -6.1581 | -5.6704 | -6.3063 | 1.2430 | 0.2979 | 0.3079 | 6.3566 |
| GSK1059615 | HCC2185 | -3.8761 | 0.9628 | -5.9776 | -5.8904 | -6.8382 | 0.9244 | 0.0998 | 0.1112 | 5.8856 |
| GSK1059615 | HCC3153 | -3.8761 | 0.9657 | -5.2936 | -5.1741 | -5.5645 | 1.1540 | 0.1244 | 0.1454 | 6.8109 |
| GSK1059615 | LY2 | -3.8761 | 0.9865 | -5.9671 | -5.8627 | -5.9883 | 3.9940 | 0.3078 | 0.3078 | 6.7193 |
| GSK1059615 | ZR75B | -3.8761 | 0.9793 | -6.3201 | -6.1835 | -6.5403 | 1.3120 | 0.1690 | 0.1695 | 5.7162 |
| Sunitinib | MCF7 | -3.7773 | 0.9778 | -5.1203 | -5.1200 | -5.2371 | 3.2140 | 0.0021 | 0.0024 | 6.5030 |