Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Omipalisib | ZR-75-1 | -4.4776 | 0.9752 | -7.6386 | -7.4713 | -8.0848 | 0.9233 | 0.1479 | 0.1496 | 4.7729 |
| Omipalisib | 184B5 | -4.4776 | 0.9563 | -7.9406 | -7.6231 | -8.2450 | 0.7444 | 0.2099 | 0.2120 | 4.7470 |
| Omipalisib | HCC1187 | -4.4776 | 0.9588 | -7.7646 | -7.5385 | -8.2829 | 0.5880 | 0.0853 | 0.1112 | 4.4995 |
| Omipalisib | MCF 10A | -4.4776 | 0.9921 | -8.0456 | -8.0015 | -8.1389 | 0.6359 | 0.0311 | 0.0362 | 3.5848 |
| Omipalisib | MCF 10F | -4.4776 | 0.9586 | -8.2176 | -8.0168 | -8.6572 | 0.7082 | 0.1396 | 0.1415 | 4.0322 |
| Omipalisib | SUM1315MO2 | -4.4776 | 0.9321 | -7.1106 | -6.5244 | -7.9823 | 0.4475 | 0.2268 | 0.2749 | 5.7439 |
| Omipalisib | SUM149PT | -4.4776 | 0.9846 | -7.2716 | -7.2716 | -7.6596 | 0.4629 | 0.0000 | 0.0484 | 4.4545 |
| Omipalisib | SUM159PT | -4.4776 | 0.9837 | -7.9746 | -7.8900 | -7.9744 | 1.1580 | 0.1009 | 0.1010 | 4.0939 |
| Omipalisib | SUM185PE | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Omipalisib | SUM225CWN | -4.4776 | 0.9049 | -8.0816 | -7.7460 | -8.7709 | 0.5508 | 0.1734 | 0.1819 | 4.3953 |
| Omipalisib | SUM229PE | -4.4776 | 0.9932 | -7.8936 | -7.7839 | -8.5529 | 0.6262 | 0.0733 | 0.0800 | 4.0235 |
| Omipalisib | SUM52PE | -4.4776 | 0.9584 | -8.2596 | -7.9596 | -8.4853 | 0.9704 | 0.2445 | 0.2447 | 4.5054 |
| Omipalisib | 184A1 | -4.4776 | 0.9136 | -8.6666 | -8.1611 | -8.7804 | 0.9289 | 0.3302 | 0.3303 | 4.7168 |
| Omipalisib | MCF12A | -4.4776 | 0.9856 | -7.9446 | -7.8784 | -8.1272 | 0.6569 | 0.0478 | 0.0528 | 3.8131 |
| Omipalisib | MX1 | -4.4776 | 0.9651 | -7.2576 | -7.2341 | -8.2892 | 0.6783 | 0.0178 | 0.0304 | 4.6065 |
| Omipalisib | T47DKBLUC | -4.4776 | 0.9730 | -7.5476 | -7.1373 | -7.7474 | 0.9674 | 0.2940 | 0.2948 | 5.5429 |
| Omipalisib | 600MPE | -4.4776 | 0.9879 | -7.1356 | -6.9475 | -8.1703 | 0.6088 | 0.1159 | 0.1367 | 5.1628 |
| Omipalisib | HCC2185 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Omipalisib | HCC3153 | -4.4776 | 0.9829 | -6.9126 | -6.4743 | -7.3853 | 0.6713 | 0.2084 | 0.2254 | 5.8680 |
| Omipalisib | LY2 | -4.4776 | 0.9684 | -7.7116 | -7.6721 | -7.9504 | 1.3520 | 0.0577 | 0.0577 | 4.3944 |
| Omipalisib | ZR75B | -4.4776 | 0.9866 | -8.1786 | -7.9344 | -8.3356 | 0.8804 | 0.1953 | 0.1957 | 4.3371 |
| GSK1059615 | MCF7 | -3.8761 | 0.9365 | -5.5426 | -4.6506 | -5.6069 | 1.2545 | 0.3940 | 0.4004 | 7.3132 |
| GSK1059615 | SK-BR-3 | -3.8761 | 0.9551 | -6.5481 | -6.3382 | -6.7890 | 1.5535 | 0.2624 | 0.2624 | 5.8849 |
| GSK1059615 | MDA-MB-231 | -3.8761 | 0.9637 | -5.3991 | -5.2956 | -5.4363 | 1.3850 | 0.1197 | 0.1260 | 6.7138 |
| GSK1059615 | AU565 | -3.8761 | 0.9917 | -6.1631 | -6.1131 | -6.3731 | 1.8030 | 0.0936 | 0.0936 | 5.5245 |