Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Geldanamycin | HCC1954 | -4.0000 | 0.9622 | -8.0210 | -7.9491 | -8.0660 | 3.7070 | 0.2302 | 0.2302 | 4.3396 |
| Geldanamycin | HCC202 | -4.0000 | 0.9273 | -7.4380 | -6.5325 | -7.9531 | 0.9980 | 0.4376 | 0.4378 | 5.9257 |
| Geldanamycin | HCC38 | -4.0000 | 0.9216 | -7.5185 | -7.2882 | -7.5889 | 2.7720 | 0.3419 | 0.3419 | 5.4066 |
| Geldanamycin | HCC70 | -4.0000 | 0.9683 | -7.0095 | -6.8673 | -7.1523 | 2.9165 | 0.2951 | 0.2951 | 5.6643 |
| Geldanamycin | Hs 578T | -4.0000 | 0.9726 | -7.1870 | -7.0417 | -7.3336 | 1.6345 | 0.1871 | 0.1871 | 4.8727 |
| Geldanamycin | MB 157 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Geldanamycin | MDA-MB-134-VI | -4.0000 | 0.9301 | -7.4645 | -7.2162 | -7.7365 | 2.2730 | 0.2448 | 0.2448 | 4.9688 |
| Geldanamycin | MDA-MB-157 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Geldanamycin | MDA-MB-175-VII | -4.0000 | 0.9905 | -7.6860 | -7.5417 | -7.8110 | 2.9170 | 0.3107 | 0.3107 | 4.9876 |
| Geldanamycin | MDA-MB-361 | -4.0000 | 0.9906 | -7.7620 | -7.7279 | -7.9231 | 3.9970 | 0.1620 | 0.1620 | 4.1263 |
| Geldanamycin | MDA-MB-436 | -4.0000 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 7.1046 |
| Geldanamycin | MDA-MB-453 | -4.0000 | 0.9475 | -7.8420 | -7.7885 | -7.9081 | 3.9980 | 0.2197 | 0.2197 | 4.2811 |
| Geldanamycin | MDA-MB-468 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Geldanamycin | T47D | -4.0000 | 0.9769 | -7.6310 | -7.4618 | -7.8048 | 3.1990 | 0.3566 | 0.3566 | 5.2630 |
| Geldanamycin | UACC-812 | -4.0000 | 0.9479 | -7.6900 | -7.4889 | -7.8250 | 3.4085 | 0.3924 | 0.3924 | 5.5975 |
| Geldanamycin | UACC-893 | -4.0000 | 0.8910 | -6.8480 | -6.5253 | -7.8001 | 0.7622 | 0.2162 | 0.2215 | 5.4240 |
| Geldanamycin | ZR-75-1 | -4.0000 | 0.9712 | -7.0320 | -5.3746 | -7.0918 | 3.1540 | 0.4713 | 0.4713 | 6.5801 |
| Geldanamycin | 184B5 | -4.0000 | 0.9961 | -7.9520 | -7.9176 | -8.0712 | 3.0480 | 0.1082 | 0.1082 | 3.5639 |
| Geldanamycin | HCC1187 | -4.0000 | 0.9076 | -7.5245 | -5.4927 | -7.5667 | 3.9930 | 0.5094 | 0.5094 | 6.4473 |
| Geldanamycin | MCF 10A | -4.0000 | 0.9888 | -8.1900 | -8.1632 | -8.2354 | 2.8000 | 0.0602 | 0.0602 | 2.9586 |
| Geldanamycin | MCF 10F | -4.0000 | 0.9860 | -8.1020 | -8.0697 | -8.1444 | 2.7410 | 0.0931 | 0.0931 | 3.3677 |
| Geldanamycin | SUM1315MO2 | -4.0000 | 0.9826 | -7.0940 | -6.3297 | -7.1939 | 1.4730 | 0.4626 | 0.4626 | 6.3995 |
| Geldanamycin | SUM149PT | -4.0000 | 0.9686 | -8.1950 | -8.1819 | -8.2478 | 3.9830 | 0.0572 | 0.0572 | 2.9240 |
| Geldanamycin | SUM159PT | -4.0000 | 0.9944 | -8.1560 | -8.1410 | -8.1970 | 2.6035 | 0.0400 | 0.0400 | 2.8392 |
| Geldanamycin | SUM185PE | -4.0000 | 0.9622 | -7.6670 | -7.5819 | -7.8045 | 3.2290 | 0.2000 | 0.2000 | 4.6139 |