Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| MG-132 | 600MPE | -4.1759 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 6.3782 |
| MG-132 | HCC2185 | -4.1759 | 0.9816 | -6.5269 | -6.4975 | -6.7732 | 3.1185 | 0.0913 | 0.0913 | 5.3614 |
| MG-132 | HCC2185 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| MG-132 | HCC3153 | -4.1759 | 0.8532 | -6.7009 | -6.6745 | -6.7822 | 4.0000 | 0.1086 | 0.1086 | 5.3325 |
| MG-132 | HCC3153 | -4.1759 | 0.9919 | -6.7699 | -6.7671 | -6.8983 | 3.4200 | 0.0121 | 0.0121 | 4.7943 |
| MG-132 | LY2 | -4.1759 | 0.7144 | -6.2109 | -6.1448 | -6.1883 | 3.9980 | 0.2279 | 0.2279 | 6.6887 |
| MG-132 | LY2 | -4.1759 | 0.9620 | -6.5529 | -6.5519 | -6.6976 | 3.9960 | 0.0059 | 0.0059 | 5.1912 |
| MG-132 | ZR75B | -4.1759 | 0.7663 | -5.7979 | -5.6535 | -5.7690 | 2.4390 | 0.2778 | 0.2779 | 6.6772 |
| MG-132 | ZR75B | -4.1759 | 0.9670 | -6.2149 | -6.2049 | -6.4245 | 1.2880 | 0.0142 | 0.0165 | 5.4518 |
| Geldanamycin | MCF7 | -4.0000 | 0.9211 | -6.7860 | -4.0000 | -6.6252 | 1.4240 | 0.6161 | 0.6161 | 7.5200 |
| Geldanamycin | SK-BR-3 | -4.0000 | 0.9704 | -7.8485 | -7.4310 | -7.8868 | 1.7040 | 0.3960 | 0.3960 | 5.6592 |
| Geldanamycin | MDA-MB-231 | -4.0000 | 0.9804 | -7.7180 | -7.6512 | -7.7148 | 3.3390 | 0.2135 | 0.2135 | 4.4922 |
| Geldanamycin | AU565 | -4.0000 | 0.9559 | -7.1480 | -6.7324 | -7.2345 | 1.4540 | 0.3756 | 0.3756 | 5.9261 |
| Geldanamycin | BT-20 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Geldanamycin | BT-474 | -4.0000 | 0.9824 | -7.7705 | -7.6527 | -7.8856 | 3.5905 | 0.3031 | 0.3031 | 5.0989 |
| Geldanamycin | BT-483 | -4.0000 | 0.8326 | -6.9445 | -4.0000 | -6.8542 | 2.9365 | 0.7054 | 0.7054 | 7.7286 |
| Geldanamycin | BT-549 | -4.0000 | 0.9884 | -8.2410 | -8.2061 | -8.2620 | 3.9980 | 0.1095 | 0.1095 | 3.2904 |
| Geldanamycin | CAMA-1 | -4.0000 | 0.9505 | -7.5310 | -4.0000 | -7.5512 | 1.8140 | 0.5276 | 0.5276 | 6.4380 |
| Geldanamycin | HCC1143 | -4.0000 | 0.9375 | -7.0780 | -6.8727 | -7.1300 | 3.3455 | 0.3780 | 0.3780 | 6.1218 |
| Geldanamycin | HCC1395 | -4.0000 | 0.9017 | -7.2090 | -4.7748 | -7.4406 | 1.0421 | 0.5008 | 0.5011 | 6.5429 |
| Geldanamycin | HCC1419 | -4.0000 | 0.9568 | -7.3780 | -7.1851 | -7.4909 | 2.9660 | 0.2897 | 0.2897 | 5.6616 |
| Geldanamycin | HCC1428 | -4.0000 | 0.9545 | -7.4585 | -5.3837 | -7.5179 | 2.7705 | 0.5049 | 0.5049 | 6.4060 |
| Geldanamycin | HCC1569 | -4.0000 | 0.9746 | -7.3760 | -7.2331 | -7.4065 | 2.7130 | 0.2953 | 0.2953 | 5.4055 |
| Geldanamycin | HCC1806 | -4.0000 | 0.9601 | -7.0230 | -6.8637 | -7.1420 | 0.9641 | 0.1714 | 0.1717 | 5.0653 |
| Geldanamycin | HCC1937 | -4.0000 | 0.9766 | -7.3950 | -7.2819 | -7.5320 | 3.1615 | 0.2601 | 0.2601 | 5.2024 |