Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Sigma A6730 | SUM149PT | -4.1759 | 0.9556 | -4.9489 | -4.9489 | -5.0706 | 1.6510 | 0.0000 | 0.0528 | 7.2335 |
| Sigma A6730 | SUM159PT | -4.1759 | 0.9428 | -5.1401 | -5.1399 | -5.1681 | 1.8310 | 0.0000 | 0.0182 | 6.9102 |
| Sigma A6730 | SUM185PE | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Sigma A6730 | SUM225CWN | -4.1759 | 0.8847 | -5.5194 | -5.5195 | -6.3932 | 0.7481 | 0.0000 | 0.0922 | 6.1228 |
| Sigma A6730 | SUM229PE | -4.1759 | 0.8718 | -4.8317 | -4.8317 | -4.9980 | 1.3400 | 0.0000 | 0.1168 | 6.9316 |
| Sigma A6730 | SUM52PE | -4.1759 | 0.9694 | -5.4989 | -5.4938 | -5.8755 | 0.9343 | 0.0054 | 0.0607 | 6.6402 |
| Sigma A6730 | 184A1 | -4.1759 | 0.9677 | -5.2029 | -5.2028 | -5.5829 | 0.7710 | 0.0000 | 0.1391 | 6.8983 |
| Sigma A6730 | MCF12A | -4.1759 | 0.9340 | -4.8256 | -4.8256 | -5.0081 | 1.3597 | 0.0000 | 0.1273 | 7.3651 |
| Sigma A6730 | MX1 | -4.1759 | 0.9440 | -5.1408 | -5.1408 | -5.4682 | 1.6540 | 0.0000 | 0.0286 | 7.1026 |
| Sigma A6730 | T47DKBLUC | -4.1759 | 0.9110 | -5.1714 | -4.8917 | -5.3937 | 0.8954 | 0.2192 | 0.3080 | 7.1676 |
| Sigma A6730 | 600MPE | -4.1759 | 0.9375 | -4.8636 | -4.8635 | -5.2631 | 1.5730 | 0.0000 | 0.0765 | 7.0695 |
| Sigma A6730 | HCC2185 | -4.1759 | 0.8925 | -4.9805 | -4.9313 | -5.8682 | 0.9313 | 0.0477 | 0.1914 | 7.3255 |
| Sigma A6730 | HCC3153 | -4.1759 | 0.8693 | -4.4800 | -4.4856 | -5.0172 | 1.1539 | 0.0000 | 0.2899 | 7.5088 |
| Sigma A6730 | LY2 | -4.1759 | 0.8583 | -5.3754 | -5.3752 | -5.8448 | 1.2155 | 0.0000 | 0.0344 | 6.4846 |
| Sigma A6730 | ZR75B | -4.1759 | 0.8789 | -5.5489 | -5.5491 | -6.0252 | 0.5413 | 0.0000 | 0.1530 | 6.1355 |
| GSK1070916 | MCF7 | -4.4776 | 0.8992 | -4.8142 | -4.8141 | -4.9891 | 2.6155 | 0.0000 | 0.1991 | 8.0618 |
| GSK1070916 | SK-BR-3 | -4.4776 | 0.9215 | -5.1088 | -4.9540 | -5.2937 | 2.7030 | 0.2897 | 0.2978 | 8.0531 |
| GSK1070916 | MDA-MB-231 | -4.4776 | 0.8912 | -5.4548 | -5.4547 | -5.5379 | 0.9323 | 0.0000 | 0.1121 | 6.9162 |
| GSK1070916 | AU565 | -4.4776 | 0.7600 | -5.2504 | -5.2504 | -5.5873 | 0.5535 | 0.0000 | 0.2719 | 6.7505 |
| GSK1070916 | BT-20 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| GSK1070916 | BT-474 | -4.4776 | 0.9390 | -4.8892 | -4.8892 | -5.1976 | 1.5185 | 0.0000 | 0.1965 | 7.9844 |
| GSK1070916 | BT-483 | -4.4776 | 0.8340 | -4.5853 | -4.4776 | -5.3674 | 0.9554 | 0.0000 | 0.5396 | 8.0951 |
| GSK1070916 | BT-549 | -4.4776 | 0.9202 | -5.5546 | -5.5550 | -5.7306 | 1.1150 | 0.0000 | 0.0592 | 6.7898 |
| GSK1070916 | CAMA-1 | -4.4776 | 0.9256 | -4.6946 | -4.6945 | -5.0755 | 1.3570 | 0.0000 | 0.3367 | 7.9134 |
| GSK1070916 | HCC1143 | -4.4776 | 0.8423 | -5.0857 | -5.0857 | -5.6528 | 1.0369 | 0.0000 | 0.1906 | 7.2557 |