Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Tozasertib | T47DKBLUC | -4.0000 | 0.9604 | -4.2170 | -4.2169 | -4.4951 | 1.3030 | 0.0000 | 0.3428 | 8.1597 |
| Tozasertib | 600MPE | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Tozasertib | HCC2185 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Tozasertib | HCC3153 | -4.0000 | 0.9569 | -4.5640 | -4.5330 | -4.6594 | 3.9990 | 0.1242 | 0.1290 | 7.8870 |
| Tozasertib | LY2 | -4.0000 | 0.7365 | -5.0460 | -5.0458 | -6.0259 | 0.4839 | 0.0000 | 0.2377 | 6.2912 |
| Tozasertib | ZR75B | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Imatinib | MCF7 | -3.2480 | 0.9699 | -4.5890 | -4.5889 | -4.7959 | 2.0400 | 0.0000 | 0.0019 | 6.5013 |
| Imatinib | SK-BR-3 | -3.2480 | 0.9738 | -4.5320 | -4.5315 | -4.6358 | 2.5155 | 0.0018 | 0.0029 | 6.3929 |
| Imatinib | MDA-MB-231 | -3.2480 | 0.8984 | -4.6860 | -4.6859 | -4.8678 | 1.6770 | 0.0000 | 0.0021 | 6.0114 |
| Imatinib | AU565 | -3.2480 | 0.9768 | -4.6470 | -4.6466 | -4.7322 | 2.2870 | 0.0000 | 0.0007 | 6.4509 |
| Imatinib | BT-20 | -3.2480 | 0.9642 | -4.5610 | -4.5611 | -4.8484 | 1.9750 | 0.0000 | 0.0028 | 6.4287 |
| Imatinib | BT-474 | -3.2480 | 0.9719 | -4.3865 | -4.3844 | -4.5539 | 3.5015 | 0.0071 | 0.0072 | 7.1381 |
| Imatinib | BT-483 | -3.2480 | 0.9598 | -4.3210 | -4.3198 | -4.5408 | 3.4310 | 0.0054 | 0.0056 | 6.5886 |
| Imatinib | BT-549 | -3.2480 | 0.9758 | -4.5030 | -4.5034 | -4.5287 | 3.7630 | 0.0000 | 0.0000 | 6.9489 |
| Imatinib | CAMA-1 | -3.2480 | 0.9889 | -4.5860 | -4.5847 | -4.7328 | 3.1970 | 0.0056 | 0.0059 | 6.5864 |
| Imatinib | HCC1143 | -3.2480 | 0.9749 | -4.5030 | -4.5032 | -4.5783 | 3.5030 | 0.0006 | 0.0007 | 6.7375 |
| Imatinib | HCC1395 | -3.2480 | 0.9806 | -4.5505 | -4.5496 | -4.7202 | 3.8375 | 0.0032 | 0.0032 | 6.6410 |
| Imatinib | HCC1419 | -3.2480 | 0.9854 | -4.4645 | -4.4631 | -4.6953 | 3.8055 | 0.0051 | 0.0051 | 6.7375 |
| Imatinib | HCC1428 | -3.2480 | 0.9867 | -4.5310 | -4.5302 | -4.7440 | 2.5995 | 0.0000 | 0.0007 | 6.6634 |
| Imatinib | HCC1569 | -3.2480 | 0.9764 | -4.5920 | -4.5922 | -4.7569 | 1.8470 | 0.0000 | 0.0036 | 6.4402 |
| Imatinib | HCC1806 | -3.2480 | 0.9836 | -5.1410 | -5.1337 | -5.2206 | 2.3450 | 0.0196 | 0.0196 | 5.7534 |
| Imatinib | HCC1937 | -3.2480 | 0.9771 | -4.5720 | -4.5718 | -4.6962 | 2.4660 | 0.0000 | 0.0005 | 6.3870 |
| Imatinib | HCC1954 | -3.2480 | 0.9816 | -4.9230 | -4.9208 | -5.0391 | 2.2800 | 0.0093 | 0.0099 | 6.1273 |
| Imatinib | HCC202 | -3.2480 | 0.9758 | -4.5180 | -4.5184 | -4.8428 | 2.3060 | 0.0000 | 0.0012 | 6.4927 |
| Imatinib | HCC38 | -3.2480 | 0.9826 | -4.4495 | -4.4491 | -4.5222 | 3.7970 | 0.0011 | 0.0011 | 6.8741 |