Cetuximab - Antibody (ID:80078)
HMS LINCS ID: | 80078 |
Name: | Cetuximab |
Alternative Names: | Erbitux |
Clone Name: | |
Resource Identification Initiative ID: | |
LINCS ID: | |
Type: | engineered |
Nominal Protein Target(s): | EGFR |
Nominal Protein Target HMS LINCS ID(s): | 200507 |
Nominal Non-protein Target: | |
Organism of Nominal Target: | Homo sapiens |
Other Target Information: | binds specifically to the extracellular domain of human EGFR (source: Bristol-Myers Squibb) |
Other Human Protein Target HMS LINCS ID(s): | |
Immunogen: | |
Immunogen Sequence: | |
Fc Domain Source Species: | human |
Clonality: | monoclonal |
Fc Domain Isotype: | IgG1 |
Source Organism for Production: | murine myeloma cells |
Production Details: | recombinant, human/mouse chimeric monoclonal antibody (chimerized from mouse monoloclonal antibody 225); composed of the Fv regions of the murine anti-EGFR antibody with human IgG1 heavy and kappa light chain constant regions; produced in mammalian (murine myeloma) cell culture (source: Bristol-Myers Squibb) |
Conjugate or Label: | |
Labeling Details: | |
Relevant Citations: | |
Comments: | |
Date Publicly Available: | 2016-09-16 |
Most Recent Update: | 2016-09-16 |
Datasets:
HMS Dataset ID | Dataset Title | HMS Dataset Type |
---|---|---|
20268 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. | Analysis |
20269 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. | Analysis |
20270 | Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. | Analysis |
Batch Information:
HMS LINCS Batch ID | Provider | Provider Catalog ID | Provider Batch ID |
---|---|---|---|
80078-1 | Bristol-Myers Squibb |