Cetuximab - Antibody (ID:80078)

HMS LINCS ID: 80078
Name: Cetuximab
Alternative Names: Erbitux
Clone Name:
Resource Identification Initiative ID:
LINCS ID:
Type: engineered
Nominal Protein Target(s): EGFR
Nominal Protein Target HMS LINCS ID(s): 200507
Nominal Non-protein Target:
Organism of Nominal Target: Homo sapiens
Other Target Information: binds specifically to the extracellular domain of human EGFR (source: Bristol-Myers Squibb)
Other Human Protein Target HMS LINCS ID(s):
Immunogen:
Immunogen Sequence:
Fc Domain Source Species: human
Clonality: monoclonal
Fc Domain Isotype: IgG1
Source Organism for Production: murine myeloma cells
Production Details: recombinant, human/mouse chimeric monoclonal antibody (chimerized from mouse monoloclonal antibody 225); composed of the Fv regions of the murine anti-EGFR antibody with human IgG1 heavy and kappa light chain constant regions; produced in mammalian (murine myeloma) cell culture (source: Bristol-Myers Squibb)
Conjugate or Label:
Labeling Details:
Relevant Citations:
Comments:
Date Publicly Available: 2016-09-16
Most Recent Update: 2016-09-16

Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20268
Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates.
Analysis
20269
Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics.
Analysis
20270
Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen.
Analysis

Batch Information:

HMS LINCS Batch ID Provider Provider Catalog ID Provider Batch ID
80078-1 Bristol-Myers Squibb