Highly-multiplexed imaging by Cyclic Immunofluorescence (CycIF) of protein levels and protein phosphorylation states in the MCF 10A breast cell line treated with EGF or four kinase inhibitors - Dataset (ID:20267)
- Detail
- Small Molecules Studied
- Cell Lines Studied
- Proteins Studied
- Antibodies Studied
- Other Reagents Studied
- Results
Proteins Studied
Download: Excel (XLSX), Comma-separated (CSV)
| LINCS ID | Name | HMS LINCS ID | UniProt ID | Alternative Names | Provider | Mutation | Phosphlorylation State | Domain | Protein Description |
|---|---|---|---|---|---|---|---|---|---|
| 201304 | ERK-2 (pT185; pY187) | 201304 | P28482 | pT185; pY187 | |||||
| 200482 | Akt-1 | 200482 | P31749 | RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha | |||||
| 200483 | Akt-2 | 200483 | P31751 | RAC-beta serine/threonine-protein kinase; Protein kinase Akt-2; Protein kinase B beta; PKB beta; RAC-PK-beta | |||||
| 200598 | VEGFR-2 | 200598 | P35968 | Vascular endothelial growth factor receptor 2; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; KDR; Protein-tyrosine kinase receptor flk-1; CD309; VEGFR2 | |||||
| 201295 | p21 | 201295 | P38936 | Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6 | |||||
| 200537 | mTOR | 200537 | P42345 | Serine/threonine-protein kinase mTOR; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; Mechanistic target of rapamycin; Rapamycin and FKBP12 target 1; Rapamycin target protein 1 | |||||
| 201296 | KI-67 | 201296 | P46013 | Antigen KI-67 | |||||
| 201344 | p27Kip1 | 201344 | P46527 | Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27 | |||||
| 201309 | K6C | 201309 | P48668 | Keratin, type II cytoskeletal 6C; Cytokeratin-6C; CK-6C; Cytokeratin-6E; CK-6E; Keratin K6h; Keratin-6C; Type-II keratin Kb12 | |||||
| 201316 | Beta-actin | 201316 | P60709 | Actin, cytoplasmic 1 | |||||
| 201299 | S6 (pS240; pS244) | 201299 | P62753 | pS240; pS244 | |||||
| 201298 | S6 (pS235; pS236) | 201298 | P62753 | pS235; pS236 | |||||
| 201342 | S6 | 201342 | P62753 | 40S ribosomal protein S6, Phosphoprotein NP33 | |||||
| 201294 | H3 (pS10) | 201294 | P68431 | pS10 | |||||
| 201349 | NF-kB p65 | 201349 | Q04206 | Transcription factor p65; Nuclear factor NF-kappa-B p65 subunit; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 | |||||
| 201352 | BAX | 201352 | Q07812 | Apoptosis regulator BAX; Bcl-2-like protein 4; Bcl2-L-4 | |||||
| 201340 | Aurora kinase B (pT232) | 201340 | Q96GD4 | pT232 | |||||
| 201341 | Aurora kinase C (pT198) | 201341 | Q9UQB9 | pT198 | |||||
| 200484 | Akt-3 | 200484 | Q9Y243 | RAC-gamma serine/threonine-protein kinase; Protein kinase Akt-3; Protein kinase B gamma; PKB gamma; RAC-PK-gamma; STK-2 |