GSK-1363089 KINOMEscan - Dataset - HMS LINCS Database

GSK-1363089 KINOMEscan - Dataset (ID:20176)

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Small molecules	Proteins

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Small Molecule	Protein	Kd	Conc unit
Foretinib	AAK1		nM
Foretinib	ABL1(E255K)-phosphorylated	150.0	nM
Foretinib	ABL1(F317I)-nonphosphorylated	40.0	nM
Foretinib	ABL1(F317I)-phosphorylated	250.0	nM
Foretinib	ABL1(F317L)-nonphosphorylated	20.0	nM
Foretinib	ABL1(F317L)-phosphorylated	170.0	nM
Foretinib	ABL1(H396P)-nonphosphorylated	10.0	nM
Foretinib	ABL1(H396P)-phosphorylated	110.0	nM
Foretinib	ABL1(M351T)-phosphorylated	36.0	nM
Foretinib	ABL1(Q252H)-nonphosphorylated	4.0	nM
Foretinib	ABL1(Q252H)-phosphorylated	120.0	nM
Foretinib	ABL1(T315I)-nonphosphorylated	18.0	nM
Foretinib	ABL1(T315I)-phosphorylated	310.0	nM
Foretinib	ABL1(Y253F)-phosphorylated	37.0	nM
Foretinib	ABL1-nonphosphorylated	5.6	nM
Foretinib	ABL1-phosphorylated	56.0	nM
Foretinib	ABL2	27.0	nM
Foretinib	ACVR1		nM
Foretinib	ACVR1B		nM
Foretinib	ACVR2A		nM
Foretinib	ACVR2B		nM
Foretinib	ACVRL1		nM
Foretinib	ADCK3		nM
Foretinib	ADCK4		nM
Foretinib	AKT1		nM
Foretinib	AKT2		nM
Foretinib	AKT3		nM
Foretinib	ALK	69.0	nM
Foretinib	AMPK-alpha1	730.0	nM
Foretinib	AMPK-alpha2	1200.0	nM
Foretinib	ANKK1	1500.0	nM
Foretinib	NUAK1		nM
Foretinib	M3K5		nM
Foretinib	M3K6		nM
Foretinib	AURKA	440.0	nM
Foretinib	AURKB	43.0	nM
Foretinib	AURKC	12.0	nM
Foretinib	AXL	0.1	nM
Foretinib	BIKE		nM
Foretinib	BLK	5.4	nM
Foretinib	BMPR1A		nM
Foretinib	BMPR1B		nM
Foretinib	BMPR2		nM
Foretinib	BMX	200.0	nM
Foretinib	BRAF	3500.0	nM
Foretinib	BRAF(V600E)	2300.0	nM
Foretinib	PTK6	4.3	nM
Foretinib	BRSK1		nM
Foretinib	BRSK2		nM
Foretinib	BTK	76.0	nM
Foretinib	CAMK1	5900.0	nM
Foretinib	CAMK1D	5300.0	nM
Foretinib	CAMK1G		nM
Foretinib	CAMK2A		nM
Foretinib	CAMK2B		nM
Foretinib	KCC2D		nM
Foretinib	CAMK2G		nM
Foretinib	KCC4		nM
Foretinib	KKCC1	550.0	nM
Foretinib	CAMKK2	4400.0	nM
Foretinib	CASK		nM
Foretinib	CDC2L1	640.0	nM
Foretinib	CDC2L2	480.0	nM
Foretinib	CDC2L5	210.0	nM
Foretinib	CDK11	87.0	nM
Foretinib	CDK2		nM
Foretinib	CDK3		nM
Foretinib	CDK4-cyclinD1		nM
Foretinib	CDK4-cyclinD3		nM
Foretinib	CDK5		nM
Foretinib	CDK7	3.7	nM
Foretinib	CDK8	130.0	nM
Foretinib	CDK9	1600.0	nM
Foretinib	CDKL1		nM
Foretinib	CDKL2	240.0	nM
Foretinib	CDKL3	4400.0	nM
Foretinib	CDKL5	2700.0	nM
Foretinib	CHEK1		nM
Foretinib	CHK2	57.0	nM
Foretinib	CIT	3200.0	nM
Foretinib	CLK1	550.0	nM
Foretinib	CLK2		nM
Foretinib	CLK3		nM
Foretinib	CLK4	850.0	nM
Foretinib	CSF1R	1.8	nM
Foretinib	CSK	120.0	nM
Foretinib	CSNK1A1		nM
Foretinib	CSNK1A1L		nM
Foretinib	CSNK1D		nM
Foretinib	CSNK1E	4600.0	nM
Foretinib	KC1G1		nM
Foretinib	KC1G2		nM
Foretinib	CSNK1G3		nM
Foretinib	CSNK2A1		nM
Foretinib	CSNK2A2	2800.0	nM
Foretinib	CTK		nM
Foretinib	DAPK1		nM
Foretinib	DAPK2		nM
Foretinib	DAPK3	3100.0	nM
Foretinib	DCLK1		nM
Foretinib	DCAMKL2		nM
Foretinib	DCAMKL3		nM
Foretinib	DDR1	0.2	nM
Foretinib	DDR2	3.6	nM
Foretinib	M3K12	22.0	nM
Foretinib	DMPK		nM
Foretinib	DMPK2	180.0	nM
Foretinib	DRAK1		nM
Foretinib	DRAK2		nM
Foretinib	DYRK1A		nM
Foretinib	DYRK1B		nM
Foretinib	DYRK2	2000.0	nM
Foretinib	EGFR	440.0	nM
Foretinib	EGFR(E746-A750del)	310.0	nM
Foretinib	EGFR(G719C)	120.0	nM
Foretinib	EGFR(G719S)	370.0	nM
Foretinib	EGFR(L747-E749del, A750P)	160.0	nM
Foretinib	EGFR(L747-S752del, P753S)	210.0	nM
Foretinib	EGFR(L747-T751del,Sins)	160.0	nM
Foretinib	EGFR(L858R)	190.0	nM
Foretinib	EGFR(L858R,T790M)	1800.0	nM
Foretinib	EGFR(L861Q)	86.0	nM
Foretinib	EGFR(S752-I759del)	1100.0	nM
Foretinib	EGFR(T790M)	470.0	nM
Foretinib	EIF2AK1	980.0	nM
Foretinib	EPHA1	6.2	nM
Foretinib	EPHA2	3.6	nM
Foretinib	EPHA3	1.0	nM
Foretinib	EPHA4	1.9	nM
Foretinib	EPHA5	6.6	nM
Foretinib	EPHA6	1.1	nM
Foretinib	EPHA7	2.5	nM
Foretinib	EPHA8	1.8	nM
Foretinib	EPHB1	12.0	nM
Foretinib	EPHB2	3.9	nM
Foretinib	EPHB3	85.0	nM
Foretinib	EPHB4	12.0	nM
Foretinib	EPHB6	1.3	nM
Foretinib	ERBB2	580.0	nM
Foretinib	ERBB3	1500.0	nM
Foretinib	ERBB4	610.0	nM
Foretinib	MK03		nM
Foretinib	MK01		nM
Foretinib	ERK3		nM
Foretinib	ERK4		nM
Foretinib	ERK5		nM
Foretinib	ERK8	73.0	nM
Foretinib	ERN1		nM
Foretinib	FAK1	180.0	nM
Foretinib	FER	37.0	nM
Foretinib	FES	110.0	nM
Foretinib	FGFR1	690.0	nM
Foretinib	FGFR2	800.0	nM
Foretinib	FGFR3	910.0	nM
Foretinib	FGFR3(G697C)	1600.0	nM
Foretinib	FGFR4		nM
Foretinib	FGR	40.0	nM
Foretinib	VGFR1	3.8	nM
Foretinib	FLT3	0.9	nM
Foretinib	FLT3(D835H)	1.4	nM
Foretinib	FLT3(D835Y)	2.0	nM
Foretinib	FLT3(ITD)	2.6	nM
Foretinib	FLT3(K663Q)	0.8	nM
Foretinib	FLT3(N841I)	1.5	nM
Foretinib	FLT3(R834Q)	11.0	nM
Foretinib	FLT4	1.5	nM
Foretinib	FRK	3.8	nM
Foretinib	FYN	88.0	nM
Foretinib	GAK		nM
Foretinib	GCN2(Kin.Dom.2,S808G)		nM
Foretinib	GRK1		nM
Foretinib	GRK4		nM
Foretinib	GRK7		nM
Foretinib	GSK3A		nM
Foretinib	GSK3B		nM
Foretinib	HCK	15.0	nM
Foretinib	HIPK1	420.0	nM
Foretinib	HIPK2	220.0	nM
Foretinib	HIPK3	43.0	nM
Foretinib	HIPK4	0.5	nM
Foretinib	M4K1	44.0	nM
Foretinib	HUNK	5400.0	nM
Foretinib	ICK		nM
Foretinib	IGF1R	430.0	nM
Foretinib	IKKA	5900.0	nM
Foretinib	IKKB		nM
Foretinib	IKKE	1400.0	nM
Foretinib	INSR	210.0	nM
Foretinib	INSRR	53.0	nM
Foretinib	IRAK1		nM
Foretinib	IRAK3	370.0	nM
Foretinib	IRAK4		nM
Foretinib	ITK	69.0	nM
Foretinib	JAK1(JH1domain-catalytic)		nM
Foretinib	JAK1(JH2domain-pseudokinase)		nM
Foretinib	JAK2(JH1domain-catalytic)	1500.0	nM
Foretinib	JAK3(JH1domain-catalytic)		nM
Foretinib	JNK1	5700.0	nM
Foretinib	MK09	670.0	nM
Foretinib	JNK3	3900.0	nM
Foretinib	KIT	2.5	nM
Foretinib	KIT(A829P)	3.2	nM
Foretinib	KIT(D816H)	36.0	nM
Foretinib	KIT(D816V)	9.6	nM
Foretinib	KIT(L576P)	2.7	nM
Foretinib	KIT(V559D)	2.1	nM
Foretinib	KIT(V559D,T670I)	2.4	nM
Foretinib	KIT(V559D,V654A)	7.6	nM
Foretinib	LATS1		nM
Foretinib	LATS2		nM
Foretinib	LCK	6.0	nM
Foretinib	LIMK1	680.0	nM
Foretinib	LIMK2	1700.0	nM
Foretinib	LKB1		nM
Foretinib	LOK	0.5	nM
Foretinib	LRRK2		nM
Foretinib	LRRK2(G2019S)		nM
Foretinib	LTK	110.0	nM
Foretinib	LYN	9.1	nM
Foretinib	M3K13	16.0	nM
Foretinib	MAK	1800.0	nM
Foretinib	MAP3K1		nM
Foretinib	MAP3K15		nM
Foretinib	M3K2	1900.0	nM
Foretinib	MAP3K3	4800.0	nM
Foretinib	MAP3K4	1900.0	nM
Foretinib	MAP4K2	2000.0	nM
Foretinib	M4K3	110.0	nM
Foretinib	MAP4K4	190.0	nM
Foretinib	MAP4K5	4.0	nM
Foretinib	MAPKAPK2		nM
Foretinib	MAPKAPK5		nM
Foretinib	MARK1		nM
Foretinib	MARK2		nM
Foretinib	MARK3		nM
Foretinib	MARK4		nM
Foretinib	MAST1		nM
Foretinib	MP2K1	12.0	nM
Foretinib	MP2K2	13.0	nM
Foretinib	MP2K3		nM
Foretinib	MP2K4		nM
Foretinib	MP2K5	2.5	nM
Foretinib	MP2K6		nM
Foretinib	MELK	300.0	nM
Foretinib	MERTK	0.3	nM
Foretinib	MET	1.4	nM
Foretinib	MET(M1250T)	1.0	nM
Foretinib	MET(Y1235D)	0.8	nM
Foretinib	MINK	2600.0	nM
Foretinib	MP2K7		nM

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HMS LINCS Project

GSK-1363089 KINOMEscan - Dataset (ID:20176)