Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Geldanamycin | HCC1143 | -4.0000 | 0.9375 | -7.0780 | -6.8727 | -7.1300 | 3.3455 | 0.3780 | 0.3780 | 6.1218 |
| GSK461364 | HCC70 | -4.4776 | 0.8008 | -7.0721 | -5.1370 | -7.5055 | 2.2167 | 0.2518 | 0.3533 | 6.3285 |
| Gemcitabine | MCF 10F | -3.8416 | 0.9817 | -7.0696 | -6.7141 | -7.1662 | 0.4548 | 0.1554 | 0.1832 | 4.7293 |
| Trametinib | MDA-MB-453 | -4.7773 | 0.9462 | -7.0683 | -4.7773 | -6.1307 | 1.8460 | 0.7450 | 0.7450 | 8.1288 |
| Ispinesib | MDA-MB-134-VI | -4.4776 | 0.9215 | -7.0676 | -6.8811 | -7.3984 | 1.2190 | 0.2037 | 0.2043 | 5.5852 |
| GSK923295 | HCC2185 | -4.4776 | 0.9320 | -7.0646 | -4.4776 | -7.1458 | 3.9970 | 0.5961 | 0.5961 | 7.3696 |
| 17-AAG | LY2 | -4.0000 | 0.9695 | -7.0545 | -6.9265 | -7.1532 | 1.9675 | 0.2149 | 0.2149 | 5.2425 |
| Topotecan | HCC1395 | -3.9626 | 0.9209 | -7.0486 | -6.9981 | -7.7934 | 0.4886 | 0.0366 | 0.0886 | 4.5496 |
| Triciribine | MCF12A | -4.4776 | 0.9141 | -7.0446 | -6.8181 | -7.2326 | 0.4569 | 0.0969 | 0.1536 | 5.1533 |
| Fascaplysin | MDA-MB-361 | -4.4776 | 0.9925 | -7.0436 | -7.0411 | -7.1518 | 3.9990 | 0.0040 | 0.0040 | 4.9497 |
| Omipalisib | HCC1428 | -4.4776 | 0.9389 | -7.0436 | -6.6504 | -7.5424 | 0.8643 | 0.2607 | 0.2826 | 5.9711 |
| Bortezomib | SUM225CWN | -3.7773 | 0.9664 | -7.0403 | -6.8934 | -7.3160 | 1.2120 | 0.1681 | 0.1682 | 4.8162 |
| Geldanamycin | ZR-75-1 | -4.0000 | 0.9712 | -7.0320 | -5.3746 | -7.0918 | 3.1540 | 0.4713 | 0.4713 | 6.5801 |
| Omipalisib | HCC1395 | -4.4776 | 0.9674 | -7.0311 | -6.6125 | -7.3086 | 0.9230 | 0.2903 | 0.2936 | 6.1517 |
| Triciribine | MCF 10F | -4.4776 | 0.8938 | -7.0306 | -6.9805 | -7.6879 | 0.4921 | 0.0278 | 0.0789 | 4.8002 |
| Geldanamycin | HCC1806 | -4.0000 | 0.9601 | -7.0230 | -6.8637 | -7.1420 | 0.9641 | 0.1714 | 0.1717 | 5.0653 |
| 17-AAG | HCC38 | -4.0000 | 0.9507 | -7.0200 | -6.8296 | -7.2836 | 1.4475 | 0.2327 | 0.2334 | 5.4493 |
| 17-AAG | HCC1806 | -4.0000 | 0.9833 | -7.0180 | -6.9621 | -7.0904 | 2.5740 | 0.1416 | 0.1416 | 4.9223 |
| Fascaplysin | BT-483 | -4.4776 | 0.9919 | -7.0166 | -7.0138 | -7.2225 | 3.7420 | 0.0125 | 0.0125 | 4.8829 |
| MG-132 | HCC70 | -4.1759 | 0.9651 | -7.0124 | -7.0064 | -7.2026 | 2.0495 | 0.0139 | 0.0139 | 4.4554 |
| LBH589 | HCC1143 | -4.4776 | 0.9211 | -7.0096 | -6.9462 | -7.1509 | 1.3210 | 0.0872 | 0.0876 | 5.1496 |
| Topotecan | MDA-MB-468 | -3.9626 | 0.7946 | -7.0096 | -6.7671 | -7.1240 | 1.1470 | 0.2368 | 0.2370 | 5.4412 |
| Geldanamycin | HCC70 | -4.0000 | 0.9683 | -7.0095 | -6.8673 | -7.1523 | 2.9165 | 0.2951 | 0.2951 | 5.6643 |
| Bortezomib | HCC3153 | -3.7773 | 0.9917 | -7.0073 | -7.0049 | -7.1651 | 2.4520 | 0.0078 | 0.0078 | 3.9384 |
| MG-132 | BT-20 | -4.1759 | 0.8406 | -7.0069 | -6.9822 | -7.2724 | 2.7675 | 0.0756 | 0.0756 | 4.5551 |