Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| MG-132 | SUM1315MO2 | -4.1759 | 0.9916 | -6.6184 | -6.6111 | -6.9346 | 1.7000 | 0.0153 | 0.0154 | 5.0888 |
| Epirubicin | MDA-MB-453 | -3.7645 | 0.9943 | -6.4165 | -6.4081 | -6.6511 | 1.8880 | 0.0154 | 0.0155 | 4.8011 |
| Sunitinib | MDA-MB-468 | -3.7773 | 0.9604 | -5.2273 | -5.2275 | -5.4078 | 1.2605 | 0.0000 | 0.0155 | 6.2161 |
| Carboplatin | HCC1395 | -2.8697 | 0.9769 | -4.4737 | -4.4737 | -4.9821 | 1.1440 | 0.0000 | 0.0157 | 6.2004 |
| Oxamflatin | HCC3153 | -4.1759 | 0.9586 | -5.5159 | -5.5159 | -5.8101 | 1.3400 | 0.0000 | 0.0158 | 6.5957 |
| NSC 663284 | 184B5 | -3.7773 | 0.9787 | -5.5663 | -5.5629 | -5.6520 | 3.6940 | 0.0158 | 0.0158 | 6.1108 |
| MG-132 | MDA-MB-134-VI | -4.1759 | 0.9750 | -6.5244 | -6.5185 | -6.7474 | 2.4260 | 0.0158 | 0.0158 | 4.9626 |
| Z-Leu-Leu-Norvalinal | MCF7 | -4.1759 | 0.9820 | -5.6629 | -5.6560 | -5.8182 | 1.8940 | 0.0143 | 0.0158 | 6.2138 |
| Valproic acid | HCC1428 | -1.8239 | 0.9764 | -2.8929 | -2.8884 | -3.1603 | 2.1525 | 0.0108 | 0.0159 | 6.8314 |
| Valproic acid | AU565 | -1.8239 | 0.9633 | -2.7437 | -2.7436 | -2.8960 | 1.9410 | 0.0000 | 0.0161 | 7.1314 |
| Afatinib | BT-549 | -4.1759 | 0.9310 | -5.8549 | -5.8547 | -5.9999 | 1.0630 | 0.0000 | 0.0162 | 5.5597 |
| Epirubicin | HCC1187 | -3.7645 | 0.9833 | -6.1880 | -6.1841 | -6.3978 | 3.4260 | 0.0162 | 0.0162 | 4.9992 |
| Epirubicin | MDA-MB-134-VI | -3.7645 | 0.9784 | -5.8625 | -5.8538 | -6.2772 | 1.6150 | 0.0159 | 0.0163 | 7.4569 |
| Olomoucine II | AU565 | -3.8761 | 0.9448 | -5.3221 | -5.3181 | -5.3977 | 4.0000 | 0.0164 | 0.0164 | 6.4289 |
| MG-132 | ZR75B | -4.1759 | 0.9670 | -6.2149 | -6.2049 | -6.4245 | 1.2880 | 0.0142 | 0.0165 | 5.4518 |
| Epirubicin | SUM159PT | -3.7645 | 0.9935 | -6.8275 | -6.8227 | -6.8449 | 2.8650 | 0.0166 | 0.0166 | 4.2723 |
| Ixabepilone | HCC1419 | -4.4045 | 0.9039 | -4.8488 | -4.8488 | -5.0061 | 3.9870 | 0.0000 | 0.0166 | 7.2267 |
| Bortezomib | T47DKBLUC | -3.7773 | 0.9658 | -5.3463 | -5.3452 | -5.8237 | 1.1390 | 0.0007 | 0.0168 | 6.4181 |
| CGC-11144 | MB 157 | -3.1500 | 0.9869 | -6.3030 | -6.2968 | -6.3799 | 2.3270 | 0.0168 | 0.0168 | 4.2130 |
| Afatinib | BT-20 | -4.1759 | 0.9075 | -5.3529 | -5.3531 | -5.6283 | 1.4980 | 0.0000 | 0.0169 | 6.3369 |
| Cisplatin | SUM185PE | -3.6021 | 0.9772 | -4.5070 | -4.5069 | -4.7976 | 1.9510 | 0.0000 | 0.0169 | 7.1377 |
| MG-132 | T47DKBLUC | -4.1759 | 0.9890 | -6.7419 | -6.7382 | -6.8513 | 3.9990 | 0.0169 | 0.0169 | 4.8177 |
| Z-Leu-Leu-Norvalinal | T47D | -4.1759 | 0.9856 | -6.0629 | -6.0593 | -6.2439 | 3.9995 | 0.0169 | 0.0169 | 6.0577 |
| LBH589 | SUM225CWN | -4.4776 | 0.9429 | -6.6066 | -6.5968 | -6.9399 | 1.4380 | 0.0161 | 0.0170 | 5.7102 |
| GSK1838705A | SUM229PE | -4.1759 | 0.9674 | -5.9299 | -5.8999 | -6.2471 | 1.2130 | 0.0021 | 0.0171 | 5.9400 |