Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| IKK16 | UACC-812 | -4.1759 | 0.9445 | -5.2039 | -5.2036 | -5.3619 | 3.9970 | 0.0000 | 0.0001 | 6.6843 |
| Fascaplysin | MCF 10F | -4.4776 | 0.9815 | -6.3996 | -6.3999 | -6.5768 | 2.0720 | 0.0000 | 0.0001 | 5.5879 |
| IKK16 | 600MPE | -4.1759 | 0.9757 | -5.2299 | -5.2297 | -5.3825 | 3.6970 | 0.0000 | 0.0001 | 6.7279 |
| Fascaplysin | HCC38 | -4.4776 | 0.9742 | -6.4461 | -6.4462 | -6.5732 | 2.1780 | 0.0000 | 0.0001 | 5.3893 |
| Sunitinib | BT-20 | -3.7773 | 0.9703 | -4.8163 | -4.8163 | -4.9181 | 3.9950 | 0.0000 | 0.0001 | 7.0490 |
| Sunitinib | SUM225CWN | -3.7773 | 0.9767 | -5.0768 | -5.0769 | -5.2252 | 3.1835 | 0.0000 | 0.0001 | 6.7349 |
| Fascaplysin | MDA-MB-157 | -4.4776 | 0.9457 | -6.5211 | -6.5212 | -6.7578 | 1.9595 | 0.0000 | 0.0001 | 5.3349 |
| Sunitinib | ZR-75-1 | -3.7773 | 0.9837 | -4.8408 | -4.8407 | -4.9558 | 3.8465 | 0.0000 | 0.0001 | 7.0373 |
| Imatinib | Hs 578T | -3.2480 | 0.7789 | -4.2235 | -4.2235 | -4.2478 | 3.9950 | 0.0000 | 0.0001 | 8.6178 |
| IKK16 | HCC1569 | -4.1759 | 0.9802 | -5.4279 | -5.4277 | -5.5154 | 3.0930 | 0.0000 | 0.0001 | 6.4961 |
| Sunitinib | HCC1187 | -3.7773 | 0.9785 | -5.1068 | -5.1071 | -5.2545 | 3.3595 | 0.0000 | 0.0001 | 6.7382 |
| Epirubicin | SUM149PT | -3.7645 | 0.9853 | -6.4895 | -6.4896 | -6.6626 | 1.4290 | 0.0000 | 0.0001 | 4.7674 |
| Sunitinib | BT-474 | -3.7773 | 0.9747 | -4.8004 | -4.8006 | -4.9414 | 3.9815 | 0.0000 | 0.0001 | 7.2094 |
| Sunitinib | HCC202 | -3.7773 | 0.9672 | -4.8723 | -4.8721 | -5.0692 | 3.4510 | 0.0000 | 0.0002 | 7.0261 |
| Fascaplysin | T47D | -4.4776 | 0.9854 | -6.2056 | -6.2051 | -6.3709 | 2.1810 | 0.0000 | 0.0002 | 6.1009 |
| Fascaplysin | MDA-MB-134-VI | -4.4776 | 0.9267 | -6.3986 | -6.3988 | -6.6442 | 1.9000 | 0.0000 | 0.0002 | 5.4362 |
| IKK16 | HCC1143 | -4.1759 | 0.9674 | -5.2879 | -5.2878 | -5.3755 | 3.4040 | 0.0000 | 0.0002 | 6.9751 |
| Imatinib | MX1 | -3.2480 | 0.9774 | -4.4760 | -4.4755 | -4.6443 | 3.0110 | 0.0000 | 0.0002 | 6.5052 |
| NSC 663284 | MDA-MB-134-VI | -3.7773 | 0.9715 | -5.0293 | -5.0290 | -5.1937 | 2.8900 | 0.0000 | 0.0002 | 6.5414 |
| Fascaplysin | MCF 10A | -4.4776 | 0.9668 | -6.4206 | -6.4210 | -6.4700 | 2.9050 | 0.0001 | 0.0002 | 5.8112 |
| Fascaplysin | HCC2185 | -4.4776 | 0.9710 | -6.4916 | -6.4913 | -6.8490 | 1.8110 | 0.0000 | 0.0002 | 5.3366 |
| Fascaplysin | MCF7 | -4.4776 | 0.9785 | -6.5106 | -6.5102 | -6.6917 | 1.9035 | 0.0000 | 0.0002 | 5.5745 |
| NSC 663284 | T47D | -3.7773 | 0.9713 | -5.1153 | -5.1148 | -5.2160 | 2.7490 | 0.0000 | 0.0002 | 6.4644 |
| Fascaplysin | SUM159PT | -4.4776 | 0.9625 | -6.3636 | -6.3633 | -6.4005 | 1.8710 | 0.0000 | 0.0003 | 6.0962 |
| IKK16 | MDA-MB-436 | -4.1759 | 0.9899 | -5.4689 | -5.4692 | -5.5589 | 2.7430 | 0.0000 | 0.0003 | 6.5174 |