LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist A in 2019 to assess reproducibility. Dataset 1 of 2: Normalized growth rate inhibition values. - Dataset (ID:20358)
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| Small Molecule | barcode | cell_count | frac_dead | corpse_count | cell_count_dead | row | column | agent | concentration | role | timepoint | replicate | cell_line | dead_count | fraction_dead | cell_count__time0 | dead_count__time0 | cell_count__ctrl | dead_count__ctrl | fraction_dead__ctrl | increase_fraction_dead | GRvalue |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Palbociclib | 180615_MC_06 | 1865 | 0.0291 | 28 | 27 | 11 | 4 | Palbociclib | 3.160329361 | treatment | 72 | 1 | MCF10A-GM_3 | 55 | 0.0286 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | 0.00525 | 0.3004 |
| Palbociclib | 180615_MC_07 | 2338 | 0.0524 | 87 | 40 | 6 | 18 | Palbociclib | 3.160329361 | treatment | 72 | 1 | MCF10A-GM_4 | 127 | 0.0515 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | 0.02812 | 0.3688 |
| Palbociclib | 180615_MC_07 | 2274 | 0.0361 | 53 | 31 | 10 | 16 | Palbociclib | 3.160329361 | treatment | 72 | 1 | MCF10A-GM_5 | 84 | 0.0356 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | 0.01223 | 0.3602 |
| Palbociclib | 180615_MC_07 | 2323 | 0.0269 | 16 | 47 | 11 | 18 | Palbociclib | 3.160329361 | treatment | 72 | 1 | MCF10A-GM_6 | 63 | 0.0264 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | 0.00301 | 0.3668 |
| Palbociclib | 180615_MC_08 | 2408 | 0.0557 | 105 | 35 | 4 | 13 | Palbociclib | 3.160329361 | treatment | 72 | 1 | MCF10A-GM_7 | 140 | 0.0549 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | 0.03155 | 0.3780 |
| Palbociclib | 180615_MC_08 | 2557 | 0.0303 | 52 | 27 | 9 | 18 | Palbociclib | 3.160329361 | treatment | 72 | 1 | MCF10A-GM_8 | 79 | 0.0300 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | 0.00657 | 0.3969 |
| Palbociclib | 180615_MC_08 | 2492 | 0.0299 | 48 | 28 | 11 | 20 | Palbociclib | 3.160329361 | treatment | 72 | 1 | MCF10A-GM_9 | 76 | 0.0296 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | 0.00620 | 0.3888 |
| Trametinib | 180615_MC_06 | 9738 | 0.0219 | 24 | 190 | 9 | 20 | Trametinib | 0.000332667 | treatment | 72 | 1 | MCF10A-GM_1 | 214 | 0.0215 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | -0.00189 | 0.8923 |
| Trametinib | 180615_MC_06 | 12091 | 0.0238 | 61 | 228 | 10 | 4 | Trametinib | 0.000332667 | treatment | 72 | 1 | MCF10A-GM_2 | 289 | 0.0233 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | -0.00005 | 0.9875 |
| Trametinib | 180615_MC_06 | 11303 | 0.0161 | 22 | 160 | 11 | 11 | Trametinib | 0.000332667 | treatment | 72 | 1 | MCF10A-GM_3 | 182 | 0.0158 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | -0.00755 | 0.9574 |
| Trametinib | 180615_MC_07 | 12463 | 0.0235 | 39 | 255 | 3 | 19 | Trametinib | 0.000332667 | treatment | 72 | 1 | MCF10A-GM_4 | 294 | 0.0230 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | -0.00035 | 1.0012 |
| Trametinib | 180615_MC_07 | 11067 | 0.0206 | 73 | 156 | 4 | 17 | Trametinib | 0.000332667 | treatment | 72 | 1 | MCF10A-GM_5 | 229 | 0.0203 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | -0.00313 | 0.9480 |
| Trametinib | 180615_MC_07 | 10900 | 0.0170 | 40 | 146 | 14 | 19 | Trametinib | 0.000332667 | treatment | 72 | 1 | MCF10A-GM_6 | 186 | 0.0168 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | -0.00662 | 0.9413 |
| Trametinib | 180615_MC_08 | 11422 | 0.0279 | 71 | 250 | 5 | 16 | Trametinib | 0.000332667 | treatment | 72 | 1 | MCF10A-GM_7 | 321 | 0.0273 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | 0.00394 | 0.9620 |
| Trametinib | 180615_MC_08 | 11111 | 0.0261 | 61 | 231 | 7 | 11 | Trametinib | 0.000332667 | treatment | 72 | 1 | MCF10A-GM_8 | 292 | 0.0256 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | 0.00221 | 0.9498 |
| Trametinib | 180615_MC_08 | 10787 | 0.0245 | 50 | 216 | 12 | 19 | Trametinib | 0.000332667 | treatment | 72 | 1 | MCF10A-GM_9 | 266 | 0.0241 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | 0.00067 | 0.9367 |
| Trametinib | 180615_MC_06 | 8872 | 0.0216 | 49 | 144 | 6 | 8 | Trametinib | 0.000998 | treatment | 72 | 1 | MCF10A-GM_1 | 193 | 0.0213 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | -0.00211 | 0.8527 |
| Trametinib | 180615_MC_06 | 8090 | 0.0202 | 15 | 149 | 10 | 19 | Trametinib | 0.000998 | treatment | 72 | 1 | MCF10A-GM_2 | 164 | 0.0199 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | -0.00353 | 0.8143 |
| Trametinib | 180615_MC_06 | 7248 | 0.0216 | 23 | 134 | 14 | 21 | Trametinib | 0.000998 | treatment | 72 | 1 | MCF10A-GM_3 | 157 | 0.0212 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | -0.00220 | 0.7696 |
| Trametinib | 180615_MC_07 | 8965 | 0.0155 | 19 | 120 | 5 | 5 | Trametinib | 0.000998 | treatment | 72 | 1 | MCF10A-GM_4 | 139 | 0.0153 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | -0.00813 | 0.8571 |
| Trametinib | 180615_MC_07 | 9287 | 0.0217 | 25 | 177 | 7 | 15 | Trametinib | 0.000998 | treatment | 72 | 1 | MCF10A-GM_5 | 202 | 0.0213 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | -0.00211 | 0.8720 |
| Trametinib | 180615_MC_07 | 8793 | 0.0176 | 25 | 130 | 7 | 21 | Trametinib | 0.000998 | treatment | 72 | 1 | MCF10A-GM_6 | 155 | 0.0173 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | -0.00608 | 0.8489 |
| Trametinib | 180615_MC_08 | 8865 | 0.0250 | 63 | 160 | 4 | 18 | Trametinib | 0.000998 | treatment | 72 | 1 | MCF10A-GM_7 | 223 | 0.0245 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | 0.00114 | 0.8523 |
| Trametinib | 180615_MC_08 | 8538 | 0.0241 | 25 | 181 | 9 | 19 | Trametinib | 0.000998 | treatment | 72 | 1 | MCF10A-GM_8 | 206 | 0.0236 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | 0.00016 | 0.8366 |
| Trametinib | 180615_MC_08 | 7941 | 0.0260 | 63 | 145 | 12 | 14 | Trametinib | 0.000998 | treatment | 72 | 1 | MCF10A-GM_9 | 208 | 0.0255 | 586.3 | 196.0 | 12428 | 298.5 | 0.0234 | 0.00213 | 0.8066 |