Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 0.0427 | uM | 10694.147 | 0.9492 | 0.9567 | 2.3818 | |
| Hs 578T | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 0.213 | uM | 10694.147 | 0.9246 | 0.9352 | 2.3818 | |
| Hs 578T | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 1.07 | uM | 10694.147 | 0.7832 | 0.8050 | 2.3818 | |
| Hs 578T | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 5.33 | uM | 10694.147 | 0.7205 | 0.7428 | 2.3818 | |
| Hs 578T | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 26.7 | uM | 10694.147 | 0.2752 | 0.1635 | 2.3818 | |
| Hs 578T | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 133 | uM | 10694.147 | 0.2302 | 0.0794 | 2.3818 | |
| LY2 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.000341 | uM | 10816.147 | 1.0185 | 1.0510 | 0.7283 | |
| LY2 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.00171 | uM | 10816.147 | 1.0965 | 1.2696 | 0.7283 | |
| LY2 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.00853 | uM | 10816.147 | 1.0921 | 1.2571 | 0.7283 | |
| LY2 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.0427 | uM | 10816.147 | 1.0827 | 1.2305 | 0.7283 | |
| LY2 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.213 | uM | 10816.147 | 1.0113 | 1.0311 | 0.7283 | |
| LY2 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 1.07 | uM | 10816.147 | 1.0220 | 1.0607 | 0.7283 | |
| LY2 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 5.33 | uM | 10816.147 | 0.7759 | 0.4116 | 0.7283 | |
| LY2 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 26.7 | uM | 10816.147 | 0.0123 | -0.9952 | 0.7283 | |
| LY2 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 133 | uM | 10816.147 | 0.0018 | -0.9997 | 0.7283 | |
| LY2 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.000341 | uM | 12319.147 | 0.9428 | 0.9025 | 1.1783 | |
| LY2 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.00171 | uM | 12319.147 | 0.7747 | 0.6105 | 1.1783 | |
| LY2 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.00853 | uM | 12319.147 | 1.0288 | 1.0488 | 1.1783 | |
| LY2 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.0427 | uM | 12319.147 | 0.8607 | 0.7610 | 1.1783 | |
| LY2 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 0.213 | uM | 12319.147 | 0.7737 | 0.6086 | 1.1783 | |
| LY2 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 1.07 | uM | 12319.147 | 0.8512 | 0.7445 | 1.1783 | |
| LY2 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 5.33 | uM | 12319.147 | 0.5334 | 0.1732 | 1.1783 | |
| LY2 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 26.7 | uM | 12319.147 | 0.0451 | -0.8557 | 1.1783 | |
| LY2 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 133 | uM | 12319.147 | 0.0277 | -0.9046 | 1.1783 | |
| MB 157 | Unknown | Unknown | Olomoucine II | CDK1 | CDK | 0.000341 | uM | 12580.147 | 0.9870 | 0.9883 | 2.2358 |