GSK1838705A - Small Molecule (ID:10255-999)
| HMS LINCS ID: |
10255-999
|
| Name: | GSK1838705A |
| Alternative Names: | |
| LINCS ID: | LSM-4276 |
| PubChem CID: | 25182616 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 532.23 |
| InChi: | InChI=1S/C27H29FN8O3/c1-29-26(38)23-17(28)6-5-7-18(23)31-25-16-8-10-30-24(16)33-27(34-25)32-19-13-20-15(12-21(19)39-4)9-11-36(20)22(37)14-35(2)3/h5-8,10,12-13H,9,11,14H2,1-4H3,(H,29,38)(H3,30,31,32,33,34) |
| InChi Key: | HZTYDQRUAWIZRE-UHFFFAOYSA-N |
| SMILES: | CNC(=O)C1=C(C=CC=C1F)NC2=NC(=NC3=C2C=CN3)NC4=C(C=C5CCN(C5=C4)C(=O)CN(C)C)OC |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-07-12 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
ALK, CLK1, CLK2, CLK4, FER, FES, IGF1R, INSR, INSRR, LTK, MYLK, PLK1, PTK2B, ROS1, STK33, TTK | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | AXL, CAMK4, CHEK2, CSNK1E, DAPK1, DYRK1B, GAK, GRK1, GRK7, LRRK2, MAP2K4, MAP3K19, MAPK10, MAPK8, MAPK9, PKD1, PRKD1, PRKD3, PTK2, RPS6KA1, RPS6KA3, TPTEP2-CSNK1E, TSSK1B |
3 (equivalent to 1µM ≤ Kd < 10 µM) | CSNK1D, CSNK2A1, DAPK2, DAPK3, DCLK1, DSTYK, DYRK1A, EGFR, ERBB4, FLT3, HIPK1, HIPK2, HIPK3, HIPK4, IRAK1, JAK2, JAK3, MAP2K3, MAP3K7, MERTK, OSR1, OXSR1, PHKG1, PHKG2, RIOK2, RPS6KA2, RPS6KA6, STK16, TAOK1, TAOK3, TNK1 |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20190 | GSK-1838705A KINOMEscan | KINOMEscan |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10255-999-2 |
(Kd <100 nM)