Cabozantinib - Small Molecule (ID:10194-106)

HMS LINCS ID: 10194-106
Name: Cabozantinib
Alternative Names: XL-184; BMS-907351
LINCS ID: LSM-1195
PubChem CID: 25102847
ChEBI ID:
ChEMBL ID:
Molecular Mass: 501.17
InChi: InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)
InChi Key: ONIQOQHATWINJY-UHFFFAOYSA-N
SMILES: COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
KDR, KIT, MET, RET
2
(equivalent to 100 nM ≤ Kd < 1µM)
AXL, FLT1, FLT3, FLT4, MERTK, NTRK2, ROS1, TEK, TYRO3

Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20343
Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values
 Microscopy/Imaging
20344
Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics
 Analysis

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10194-106-1 Haoyuan chemexpress HY-12044-20110919
10194-106-2 MedChem Express 09581