Foretinib - Small Molecule (ID:10157-101)
| HMS LINCS ID: |
10157-101
|
| Name: | Foretinib |
| Alternative Names: | XL880; GSK1363089 |
| LINCS ID: | LSM-1158 |
| PubChem CID: | 42642645 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 632.24 |
| InChi: | InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42) |
| InChi Key: | CXQHYVUVSFXTMY-UHFFFAOYSA-N |
| SMILES: | COC1=CC2=C(C=CN=C2C=C1OCCCN3CCOCC3)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
ABL1, ABL2, AIM1, ALK, AURKB, AURKC, AXL, BLK, BTK, CDK14, CDK15, CDK19, CDK7, CHEK2, CSF1R, DDR1, DDR2, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FER, FGR, FLT1, FLT3, FLT4, FRK, FYN, HCK, HIPK3, HIPK4, INSRR, ITK, KDR, KIT, LCK, LYN, MAP2K1, MAP2K2, MAP2K5, MAP3K12, MAP3K13, MAP3K19, MAP3K20, MAP4K1, MAP4K5, MAPK13, MAPK15, MERTK, MET, MKNK1, MKNK2, MST1R, MUSK, NTRK1, NTRK2, NTRK3, PDGFRA, PDGFRB, PIP4K2C, PLK4, PTK2B, PTK6, RET, RIPK2, ROS1, SLK, SRC, SRMS, STK10, STK33, TEK, TIE1, TKT, TNK1, TYRO3, YES1 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | AURKA, BMX, CAMKK1, CDC42BPA, CDC42BPB, CDC42BPG, CDK11A, CDK11B, CDK13, CDK16, CDK17, CDK18, CDK8, CDKL2, CLK1, CLK4, CSK, DSTYK, EGFR, EIF2AK1, ERBB2, ERBB4, FES, FGFR1, FGFR2, FLG, FPGT-TNNI3K, HIPK1, HIPK2, IGF1R, INSR, IRAK3, LIMK1, LTK, MAP3K10, MAP3K11, MAP3K7, MAP4K3, MAP4K4, MAPK11, MAPK12, MAPK14, MAPK9, MELK, MYO3B, NEK8, NEK9, NLK, PF3D7_0217500, PRKAA1, PTK2, RIPK1, RIPK4, SIK1, SIK1B, SIK2, STK35, STK36, SYK, TBK1, TEC, TESK1, TNIK, TNK2, TNNI3K, TTK, TXK, ULK3 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | ANKK1, BRAF, CAMK1, CAMK1D, CAMKK2, CDK9, CDKL3, CDKL5, CHUK, CIT, CSNK1E, CSNK2A2, DAPK3, DYRK2, ERBB3, FGFR3, HUNK, IKBKE, JAK2, LIMK2, MAK, MAP3K2, MAP3K3, MAP3K4, MAP3K9, MAP4K2, MAPK10, MAPK8, MINK1, MST1, MYLK2, MYLK3, MYO3A, PAK3, PRKAA2, PRKD3, RAF1, ROCK2, RPS6KA2, RPS6KB1, STK25, STK4, TAOK1, TAOK2, TPTEP2-CSNK1E, TYK2 |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20237 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 1 of 15: Cell count and relative growth within biological replicate 1. | Microscopy/Imaging |
| 20238 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 2 of 15: Cell count and relative growth within biological replicate 2. | Microscopy/Imaging |
| 20239 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 3 of 15: Cell count and relative growth within biological replicate 3. | Microscopy/Imaging |
| 20240 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 4 of 15: Mean cell count and mean growth rate across biological replicate 1. | Microscopy/Imaging |
| 20241 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 5 of 15: Mean cell count and mean growth rate across biological replicate 2. | Microscopy/Imaging |
| 20242 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 6 of 15: Mean cell count and mean growth rate across biological replicate 3. | Microscopy/Imaging |
| 20243 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 7 of 15: Mean cell count and mean growth rate across all replicates. | Microscopy/Imaging |
| 20245 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 8 of 15: Cell count and normalized growth rate inhibition values within biological replicate 1. | Microscopy/Imaging |
| 20246 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 9 of 15: Cell count and normalized growth rate inhibition values within biological replicate 2. | Microscopy/Imaging |
| 20247 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 10 of 15: Cell count and normalized growth rate inhibition values within biological replicate 3. | Microscopy/Imaging |
| 20248 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. | Microscopy/Imaging |
| 20249 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 12 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 2. | Microscopy/Imaging |
| 20250 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. | Microscopy/Imaging |
| 20251 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 14 of 15: Mean cell count and mean normalized growth rate inhibition values across all replicates. | Microscopy/Imaging |
| 20252 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 15 of 15: Calculated dose-response metrics. | Analysis |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10157-101-1 | Haoyuan chemexpress | HY-10338_1-20100311 |
| 10157-101-2 | Haoyuan chemexpress | HY-10338-20111209 |
(Kd <100 nM)