Olaparib - Small Molecule (ID:10144-101)

HMS LINCS ID: 10144-101
Name: Olaparib
Alternative Names: AZD2281; KU-0059436
LINCS ID: LSM-1145
PubChem CID: 23725625
ChEBI ID:
ChEMBL ID:
Molecular Mass: 434.18
InChi: InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)
InChi Key: FDLYAMZZIXQODN-UHFFFAOYSA-N
SMILES: C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
PARP1, PARP2
3
(equivalent to 1µM ≤ Kd < 10 µM)
TNKS

Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20276
Protein levels measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with Vemurafenib in combination with chromatin-targeting compounds (immunofluorescence dataset 3 of 4)
 Microscopy/Imaging
20343
Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values
 Microscopy/Imaging
20344
Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 2 of 2: Calculated dose response metrics
 Analysis

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10144-101-1 Haoyuan chemexpress HM-042_8-20100517
10144-101-2 Haoyuan chemexpress HM-042_8-20110726
10144-101-3 MedChem Express 14425