TPCA-1 - Small Molecule (ID:10136-101)
| HMS LINCS ID: |
10136-101
|
| Name: | TPCA-1 |
| Alternative Names: | |
| LINCS ID: | LSM-1136 |
| PubChem CID: | 9903786 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 279.05 |
| InChi: | InChI=1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18) |
| InChi Key: | SAYGKHKXGCPTLX-UHFFFAOYSA-N |
| SMILES: | C1=CC(=CC=C1C2=CC(=C(S2)NC(=O)N)C(=O)N)F |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
IKBKB, JAK2 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | AURKA, AURKB, BRSK1, BTK, CDK2, CHEK2, DAPK1, EIF2AK2, EPHA4, EPHB1, EPHB2, EPHB3, ERBB4, FGFR1, FLT1, GCK, IGF1R, IKBKE, IRAK4, MAP2K1, MAP2K1, MAP2K2, MAP3K1, MAP3K11, MAP3K7, MAP3K9, MAPK15, MINK1, NTRK1, NUAK1, PRKAA1, PRKAA2, PRKAB1, PRKAB2, RIPK2, RPS6KA1, SRC, SRC, STK26, STK3, TAOK1, YES1 |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20268 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. | Analysis |
| 20269 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. | Analysis |
| 20270 | Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. | Analysis |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10136-101-1 | Haoyuan chemexpress | HM-093_6-20110128 |
| 10136-101-2 | Tocris |
(Kd <100 nM)