JWE-035 - Small Molecule (ID:10092-101)
| HMS LINCS ID: |
10092-101
|
| Name: | JWE-035 |
| Alternative Names: | |
| LINCS ID: | LSM-1092 |
| PubChem CID: | 57340671 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 525.25 |
| InChi: | InChI=1S/C27H30F3N7O/c1-4-36-11-13-37(14-12-36)17-18-9-10-19(15-21(18)27(28,29)30)32-26-31-16-23-24(33-26)34(2)22-8-6-5-7-20(22)25(38)35(23)3/h5-10,15-16H,4,11-14,17H2,1-3H3,(H,31,32,33) |
| InChi Key: | PXGLIUGVLBRUBV-UHFFFAOYSA-N |
| SMILES: | CCN1CCN(CC1)CC2=C(C=C(C=C2)NC3=NC=C4C(=N3)N(C5=CC=CC=C5C(=O)N4C)C)C(F)(F)F |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
ABL1, AURKA, JAK2, MAPK7, PIK3CD, PIK3CG, PLK4, TAOK2, TAOK3, ULK1, ULK2 | |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20046 | JWE-035 KINOMEscan | KINOMEscan |
| 20100 | JWE-035 KiNativ -- single dose experiment | KiNativ |
KINOMEscan Image
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10092-101-1 | Nathanael Gray (DFCI) |
(equivalent to 100 nM ≤ Kd < 1µM)