GSK1070916 - Small Molecule (ID:10062-101)
| HMS LINCS ID: |
10062-101
|
| Name: | GSK1070916 |
| Alternative Names: | KIN001-216 |
| LINCS ID: | LSM-1062 |
| PubChem CID: | 46885626 |
| ChEBI ID: | |
| ChEMBL ID: | 1090479 |
| Molecular Mass: | 507.27 |
| InChi: | InChI=1S/C30H33N7O/c1-6-37-19-26(28(34-37)21-10-12-23(13-11-21)32-30(38)36(4)5)24-14-15-31-29-25(24)17-27(33-29)22-9-7-8-20(16-22)18-35(2)3/h7-17,19H,6,18H2,1-5H3,(H,31,33)(H,32,38) |
| InChi Key: | QTBWCSQGBMPECM-UHFFFAOYSA-N |
| SMILES: | CCN1C=C(C(=N1)C2=CC=C(C=C2)NC(=O)N(C)C)C3=C4C=C(NC4=NC=C3)C5=CC(=CC=C5)CN(C)C |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
AIM1, AURKB, AURKC, FGFR1, FLG, FLT1, FLT4, SIK1, TEK | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | AURKA |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20003 | Tang Mitosis/Apoptosis ver. II | Microscopy/Imaging |
| 20120 | Metrics other than potency reveal systematic variation in responses to cancer drugs | Analysis |
| 20268 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. | Analysis |
| 20269 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. | Analysis |
| 20270 | Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. | Analysis |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10062-101-1 | Haoyuan chemexpress | HM-040_11-20100714 |
| 10062-101-2 | Haoyuan Chemexpress | HM-040_TM-20100709 |
| 10062-101-3 |
(Kd <100 nM)