AS605240 - Small Molecule (ID:10054-101)
| HMS LINCS ID: |
10054-101
|
| Name: | AS605240 |
| Alternative Names: | |
| LINCS ID: | LSM-42784 |
| PubChem CID: | 24906273 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 257.03 |
| InChi: | InChI=1S/C12H7N3O2S/c16-11-10(18-12(17)15-11)6-7-1-2-8-9(5-7)14-4-3-13-8/h1-6H,(H,15,16,17) |
| InChi Key: | SQWZFLMPDUSYGV-UHFFFAOYSA-N |
| SMILES: | C1=CC2=NC=CN=C2C=C1C=C3C(=O)NC(=O)S3 |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2018-03-30 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
PIK3CA, PIK3CG | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | PIK3CB, PIK3CD |
3 (equivalent to 1µM ≤ Kd < 10 µM) | CISD1 |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20364 | Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 1 of 2: GR values. | Microscopy/Imaging |
| 20365 | Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. | Analysis |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10054-101-1 | Haoyuan chemexpress | HY-999-20101220 |
| 10054-101-2 | Medchem Express | 13163 |
(Kd <100 nM)