AZ-628 - Small Molecule (ID:10050-101)
| HMS LINCS ID: |
10050-101
|
| Name: | AZ-628 |
| Alternative Names: | |
| LINCS ID: | LSM-1050 |
| PubChem CID: | 11676786 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 451.20 |
| InChi: | InChI=1S/C27H25N5O2/c1-17-8-9-21(31-25(33)18-6-5-7-19(12-18)27(2,3)15-28)14-24(17)30-20-10-11-23-22(13-20)26(34)32(4)16-29-23/h5-14,16,30H,1-4H3,(H,31,33) |
| InChi Key: | ZGBGPEDJXCYQPH-UHFFFAOYSA-N |
| SMILES: | CC1=C(C=C(C=C1)NC(=O)C2=CC(=CC=C2)C(C)(C)C#N)NC3=CC4=C(C=C3)N=CN(C4=O)C |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
BRAF, CIT, CSF1R, DDR1, EPHA4, EPHA6, EPHB2, EPHB3, MAPK11, MAPK14, PDGFRA, PDGFRB, RAF1, STK10, YES1 | |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20025 | AZ-628 KINOMEscan | KINOMEscan |
| 20091 | AZ-628 KiNativ -- dose response experiment | KiNativ |
| 20217 | Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging | Microscopy/Imaging |
| 20218 | Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by Reverse Phase Protein Arrays (RPPA) | Reverse Phase Protein Array |
KINOMEscan Image
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10050-101-1 | Haoyuan chemexpress | HY-999-20100706 |
| 10050-101-2 | AstraZeneca |
(equivalent to 100 nM ≤ Kd < 1µM)