Crizotinib - Small Molecule (ID:10027-101)
| HMS LINCS ID: |
10027-101
|
| Name: | Crizotinib |
| Alternative Names: | PF02341066 |
| LINCS ID: | LSM-1027 |
| PubChem CID: | 11626560 |
| ChEBI ID: | |
| ChEMBL ID: | 601719 |
| Molecular Mass: | 449.12 |
| InChi: | InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 |
| InChi Key: | KTEIFNKAUNYNJU-GFCCVEGCSA-N |
| SMILES: | C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
ABL1, AIM1, ALK, AURKB, AXL, EPHA6, EPHB6, IRAK1, IRAK3, LCK, LTK, MAP3K2, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MERTK, MET, MST1R, NPM1, NTRK1, NTRK2, NTRK3, PLK4, ROS1, SLK, STK10 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | ABL2, ACVR1, ACVR1B, ANKK1, AURKA, BLK, BMP2K, BMPR1B, CASK, CDK11A, CDK11B, CDK7, CSF1R, DCLK1, DCLK2, DDR1, DDR2, DSTYK, EPHA1, EPHA2, EPHA3, EPHA4, EPHA7, EPHA8, EPHB1, EPHB4, FER, FES, FGR, FLT3, FPGT-TNNI3K, IGF1R, IKBKE, INSR, INSRR, JAK1, JAK2, JAK3, LIMK1, LIMK2, LYN, MAP3K12, MAP3K13, MAP3K19, MAP3K3, MAPK7, MST1, MUSK, NEK8, NEK9, NUAK2, PIP5K1A, PRKD1, PRKD3, PTK2, PTK2B, RIPK2, RPS6KB1, SBK3, SIK2, SRC, STK3, STK35, STK4, TAOK2, TAOK3, TBK1, Tek, TEK, TESK1, TIE1, TNK1, TNK2, TNNI3K, TXK, TYRO3, YES1 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | AAK1, Abl1, AURKC, BMX, BTK, CAMKK2, CDKL2, COQ8B, DMPK, DYRK2, EGFR, EIF2AK2, EPHA5, FGFR3, FLT1, FRK, FYN, GRK4, HIPK4, IKBKB, IRAK4, ITK, KIT, MAP2K3, MAP3K1, MAP3K15, MAP3K7, MINK1, NEK7, NIM1K, PKD1, PRKAA1, RET, RIOK1, RIOK3, RIPK1, RIPK4, ROCK1, ROCK2, SBK1, SRPK1, SRPK3, STK26, SYK, TAOK1, TGFBR1, TYK2, ULK1, ULK2, ULK3, ZAP70 |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20033 | PF02341066 KINOMEscan | KINOMEscan |
| 20237 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 1 of 15: Cell count and relative growth within biological replicate 1. | Microscopy/Imaging |
| 20238 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 2 of 15: Cell count and relative growth within biological replicate 2. | Microscopy/Imaging |
| 20239 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 3 of 15: Cell count and relative growth within biological replicate 3. | Microscopy/Imaging |
| 20240 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 4 of 15: Mean cell count and mean growth rate across biological replicate 1. | Microscopy/Imaging |
| 20241 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 5 of 15: Mean cell count and mean growth rate across biological replicate 2. | Microscopy/Imaging |
| 20242 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 6 of 15: Mean cell count and mean growth rate across biological replicate 3. | Microscopy/Imaging |
| 20243 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 7 of 15: Mean cell count and mean growth rate across all replicates. | Microscopy/Imaging |
| 20245 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 8 of 15: Cell count and normalized growth rate inhibition values within biological replicate 1. | Microscopy/Imaging |
| 20246 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 9 of 15: Cell count and normalized growth rate inhibition values within biological replicate 2. | Microscopy/Imaging |
| 20247 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 10 of 15: Cell count and normalized growth rate inhibition values within biological replicate 3. | Microscopy/Imaging |
| 20248 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. | Microscopy/Imaging |
| 20249 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 12 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 2. | Microscopy/Imaging |
| 20250 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. | Microscopy/Imaging |
| 20251 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 14 of 15: Mean cell count and mean normalized growth rate inhibition values across all replicates. | Microscopy/Imaging |
| 20252 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 15 of 15: Calculated dose-response metrics. | Analysis |
KINOMEscan Image
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10027-101-1 | Haoyuan chemexpress | HM-036_12-20100427 |
| 10027-101-2 | Haoyuan chemexpress | |
| 10027-101-4 | MedChem Express | 01983 |
(Kd <100 nM)