Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.0362 | uM | 7553.091 | 1.0059 | 1.0120 | 0.9738 | |
| ZR-75-1 | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.181 | uM | 7553.091 | 1.0416 | 1.0856 | 0.9738 | |
| ZR-75-1 | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.904 | uM | 7553.091 | 1.0301 | 1.0618 | 0.9738 | |
| ZR-75-1 | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 4.52 | uM | 7553.091 | 0.9796 | 0.9582 | 0.9738 | |
| ZR-75-1 | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 22.6 | uM | 7553.091 | 0.8272 | 0.6460 | 0.9738 | |
| ZR-75-1 | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 113 | uM | 7553.091 | 0.0311 | -0.9434 | 0.9738 | |
| ZR-75-1 | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 565 | uM | 7553.091 | 0.0075 | -0.9869 | 0.9738 | |
| ZR75B | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.00145 | uM | 7555.091 | 0.9886 | 0.9858 | 1.6040 | |
| ZR75B | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.00723 | uM | 7555.091 | 1.0173 | 1.0216 | 1.6040 | |
| ZR75B | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.0362 | uM | 7555.091 | 1.0171 | 1.0213 | 1.6040 | |
| ZR75B | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.181 | uM | 7555.091 | 0.9940 | 0.9925 | 1.6040 | |
| ZR75B | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.904 | uM | 7555.091 | 1.0729 | 1.0897 | 1.6040 | |
| ZR75B | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 4.52 | uM | 7555.091 | 1.0764 | 1.0939 | 1.6040 | |
| ZR75B | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 22.6 | uM | 7555.091 | 0.7408 | 0.6588 | 1.6040 | |
| ZR75B | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 113 | uM | 7555.091 | 0.0446 | -0.7125 | 1.6040 | |
| ZR75B | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 565 | uM | 7555.091 | 0.0082 | -0.8997 | 1.6040 | |
| 184A1 | NM | Basal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 5894.067 | 1.0705 | 1.0890 | 1.5647 | |
| 184A1 | NM | Basal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 5894.067 | 1.0555 | 1.0702 | 1.5647 | |
| 184A1 | NM | Basal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 5894.067 | 1.0509 | 1.0644 | 1.5647 | |
| 184A1 | NM | Basal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 5894.067 | 1.0516 | 1.0654 | 1.5647 | |
| 184A1 | NM | Basal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 5894.067 | 0.7768 | 0.7018 | 1.5647 | |
| 184A1 | NM | Basal | Ispinesib | KSP | Kinesin | 0.267 | uM | 5894.067 | 0.7609 | 0.6796 | 1.5647 | |
| 184A1 | NM | Basal | Ispinesib | KSP | Kinesin | 1.33 | uM | 5894.067 | 0.7698 | 0.6921 | 1.5647 | |
| 184A1 | NM | Basal | Ispinesib | KSP | Kinesin | 6.67 | uM | 5894.067 | 0.1248 | -0.4709 | 1.5647 | |
| 184A1 | NM | Basal | Ispinesib | KSP | Kinesin | 33.3 | uM | 5894.067 | 0.0054 | -0.9288 | 1.5647 |