Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MB 157 | Unknown | Unknown | Nilotinib | ABL | nRTK | 200 | uM | 12580.17 | 0.8725 | 0.8681 | 1.9993 | |
| MCF 10A | NM | Basal B | Nilotinib | ABL | nRTK | 0.000512 | uM | 11056.145 | 1.0385 | 1.0268 | 2.8383 | |
| MCF 10A | NM | Basal B | Nilotinib | ABL | nRTK | 0.00256 | uM | 11056.145 | 1.0994 | 1.0679 | 2.8383 | |
| MCF 10A | NM | Basal B | Nilotinib | ABL | nRTK | 0.0128 | uM | 11056.145 | 1.0531 | 1.0368 | 2.8383 | |
| MCF 10A | NM | Basal B | Nilotinib | ABL | nRTK | 0.064 | uM | 11056.145 | 1.1631 | 1.1094 | 2.8383 | |
| MCF 10A | NM | Basal B | Nilotinib | ABL | nRTK | 0.32 | uM | 11056.145 | 1.0660 | 1.0455 | 2.8383 | |
| MCF 10A | NM | Basal B | Nilotinib | ABL | nRTK | 1.6 | uM | 11056.145 | 1.0658 | 1.0454 | 2.8383 | |
| MCF 10A | NM | Basal B | Nilotinib | ABL | nRTK | 8 | uM | 11056.145 | 0.9672 | 0.9766 | 2.8383 | |
| MCF 10A | NM | Basal B | Nilotinib | ABL | nRTK | 40 | uM | 11056.145 | 1.1172 | 1.0796 | 2.8383 | |
| MCF 10A | NM | Basal B | Nilotinib | ABL | nRTK | 200 | uM | 11056.145 | 1.0967 | 1.0661 | 2.8383 | |
| MCF 10F | NM | - | Nilotinib | ABL | nRTK | 0.000512 | uM | 12254.145 | 1.0585 | 1.0647 | 1.7869 | |
| MCF 10F | NM | - | Nilotinib | ABL | nRTK | 0.00256 | uM | 12254.145 | 1.0513 | 1.0568 | 1.7869 | |
| MCF 10F | NM | - | Nilotinib | ABL | nRTK | 0.0128 | uM | 12254.145 | 1.0114 | 1.0127 | 1.7869 | |
| MCF 10F | NM | - | Nilotinib | ABL | nRTK | 0.064 | uM | 12254.145 | 1.0249 | 1.0277 | 1.7869 | |
| MCF 10F | NM | - | Nilotinib | ABL | nRTK | 0.32 | uM | 12254.145 | 1.0539 | 1.0596 | 1.7869 | |
| MCF 10F | NM | - | Nilotinib | ABL | nRTK | 1.6 | uM | 12254.145 | 0.9262 | 0.9161 | 1.7869 | |
| MCF 10F | NM | - | Nilotinib | ABL | nRTK | 8 | uM | 12254.145 | 0.9927 | 0.9918 | 1.7869 | |
| MCF 10F | NM | - | Nilotinib | ABL | nRTK | 40 | uM | 12254.145 | 0.9713 | 0.9677 | 1.7869 | |
| MCF 10F | NM | - | Nilotinib | ABL | nRTK | 200 | uM | 12254.145 | 0.9049 | 0.8912 | 1.7869 | |
| MCF12A | NM | Basal B | Nilotinib | ABL | nRTK | 0.000512 | uM | 10817.145 | 1.0017 | 1.0022 | 1.5564 | |
| MCF12A | NM | Basal B | Nilotinib | ABL | nRTK | 0.00256 | uM | 10817.145 | 0.8909 | 0.8569 | 1.5564 | |
| MCF12A | NM | Basal B | Nilotinib | ABL | nRTK | 0.0128 | uM | 10817.145 | 0.9868 | 0.9830 | 1.5564 | |
| MCF12A | NM | Basal B | Nilotinib | ABL | nRTK | 0.064 | uM | 10817.145 | 0.9930 | 0.9910 | 1.5564 | |
| MCF12A | NM | Basal B | Nilotinib | ABL | nRTK | 0.32 | uM | 10817.145 | 1.0139 | 1.0178 | 1.5564 | |
| MCF12A | NM | Basal B | Nilotinib | ABL | nRTK | 1.6 | uM | 10817.145 | 0.9181 | 0.8932 | 1.5564 |