LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | OSI-027 | 0.37 | uM | LJP6 | 72 | hr | 1476 | 1909 | 3643 | 0.5236 | 0.2147 |
| SK-BR-3 | OSI-027 | 1.11 | uM | LJP6 | 72 | hr | 1476 | 1848 | 3643 | 0.5078 | 0.1872 |
| SK-BR-3 | OSI-027 | 3.33 | uM | LJP6 | 72 | hr | 1476 | 1799 | 3643 | 0.4942 | 0.1630 |
| SK-BR-3 | OSI-027 | 10 | uM | LJP6 | 72 | hr | 1476 | 1650 | 3643 | 0.4551 | 0.0919 |
| SK-BR-3 | WYE-125132 | 0.04 | uM | LJP6 | 72 | hr | 1476 | 1756 | 3643 | 0.4798 | 0.1336 |
| SK-BR-3 | WYE-125132 | 0.12 | uM | LJP6 | 72 | hr | 1476 | 1563 | 3643 | 0.4283 | 0.0406 |
| SK-BR-3 | WYE-125132 | 0.37 | uM | LJP6 | 72 | hr | 1476 | 1538 | 3643 | 0.4190 | 0.0191 |
| SK-BR-3 | WYE-125132 | 1.11 | uM | LJP6 | 72 | hr | 1476 | 1617 | 3643 | 0.4413 | 0.0621 |
| SK-BR-3 | WYE-125132 | 3.33 | uM | LJP6 | 72 | hr | 1476 | 1411 | 3643 | 0.3857 | -0.0408 |
| SK-BR-3 | WYE-125132 | 10 | uM | LJP6 | 72 | hr | 1476 | 1510 | 3643 | 0.4125 | 0.0092 |
| SK-BR-3 | Barasertib | 0.04 | uM | LJP5 | 72 | hr | 1476 | 1428 | 3772 | 0.3787 | -0.0243 |
| SK-BR-3 | Barasertib | 0.12 | uM | LJP5 | 72 | hr | 1476 | 1430 | 3772 | 0.3791 | -0.0236 |
| SK-BR-3 | Barasertib | 0.37 | uM | LJP5 | 72 | hr | 1476 | 1420 | 3772 | 0.3765 | -0.0286 |
| SK-BR-3 | Barasertib | 1.11 | uM | LJP5 | 72 | hr | 1476 | 1433 | 3772 | 0.3800 | -0.0220 |
| SK-BR-3 | Barasertib | 3.33 | uM | LJP5 | 72 | hr | 1476 | 1392 | 3772 | 0.3693 | -0.0423 |
| SK-BR-3 | Barasertib | 10 | uM | LJP5 | 72 | hr | 1476 | 1365 | 3772 | 0.3621 | -0.0563 |
| SK-BR-3 | Vemurafenib | 0.04 | uM | LJP5 | 72 | hr | 1476 | 4001 | 3772 | 1.0608 | 1.0889 |
| SK-BR-3 | Vemurafenib | 0.12 | uM | LJP5 | 72 | hr | 1476 | 3973 | 3772 | 1.0535 | 1.0786 |
| SK-BR-3 | Vemurafenib | 0.37 | uM | LJP5 | 72 | hr | 1476 | 3877 | 3772 | 1.0279 | 1.0403 |
| SK-BR-3 | Vemurafenib | 1.11 | uM | LJP5 | 72 | hr | 1476 | 3752 | 3772 | 0.9946 | 0.9919 |
| SK-BR-3 | Vemurafenib | 3.33 | uM | LJP5 | 72 | hr | 1476 | 3666 | 3772 | 0.9719 | 0.9581 |
| SK-BR-3 | Vemurafenib | 10 | uM | LJP5 | 72 | hr | 1476 | 3200 | 3772 | 0.8482 | 0.7706 |
| SK-BR-3 | Enzastaurin | 0.04 | uM | LJP5 | 72 | hr | 1476 | 4294 | 3772 | 1.1386 | 1.2015 |
| SK-BR-3 | Enzastaurin | 0.12 | uM | LJP5 | 72 | hr | 1476 | 4205 | 3772 | 1.1149 | 1.1672 |
| SK-BR-3 | Enzastaurin | 0.37 | uM | LJP5 | 72 | hr | 1476 | 4089 | 3772 | 1.0842 | 1.1232 |