Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7552.084 | 0.9959 | 0.9927 | 1.1307 | |
| ZR-75-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 7552.084 | 0.9535 | 0.9175 | 1.1307 | |
| ZR-75-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.267 | uM | 7552.084 | 0.8061 | 0.6528 | 1.1307 | |
| ZR-75-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7552.084 | 0.0611 | -0.8312 | 1.1307 | |
| ZR-75-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7552.084 | 0.0092 | -0.9685 | 1.1307 | |
| ZR-75-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7552.084 | 0.0079 | -0.9725 | 1.1307 | |
| ZR-75-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7553.085 | 1.0135 | 1.0240 | 1.1198 | |
| ZR-75-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7553.085 | 0.9985 | 0.9973 | 1.1198 | |
| ZR-75-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7553.085 | 1.0303 | 1.0540 | 1.1198 | |
| ZR-75-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7553.085 | 1.0168 | 1.0299 | 1.1198 | |
| ZR-75-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 7553.085 | 0.9909 | 0.9838 | 1.1198 | |
| ZR-75-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.267 | uM | 7553.085 | 0.8283 | 0.6904 | 1.1198 | |
| ZR-75-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7553.085 | 0.1262 | -0.6851 | 1.1198 | |
| ZR-75-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7553.085 | 0.0130 | -0.9588 | 1.1198 | |
| ZR-75-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7553.085 | 0.0073 | -0.9753 | 1.1198 | |
| ZR75B | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7555.084 | 1.0284 | 1.0331 | 1.7052 | |
| ZR75B | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7555.084 | 0.9544 | 0.9460 | 1.7052 | |
| ZR75B | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7555.084 | 1.0249 | 1.0290 | 1.7052 | |
| ZR75B | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7555.084 | 0.9161 | 0.8998 | 1.7052 | |
| ZR75B | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 7555.084 | 0.9082 | 0.8901 | 1.7052 | |
| ZR75B | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.267 | uM | 7555.084 | 0.8147 | 0.7735 | 1.7052 | |
| ZR75B | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7555.084 | 0.0437 | -0.6809 | 1.7052 | |
| ZR75B | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7555.084 | 0.0103 | -0.8636 | 1.7052 | |
| ZR75B | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7555.084 | 0.0080 | -0.8819 | 1.7052 | |
| 184A1 | NM | Basal | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 12509.166 | 1.0036 | 1.0057 | 1.2847 |