Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by Reverse Phase Protein Arrays (RPPA) - Dataset (ID:20218)
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Small Molecule | Cell Line | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Replicate | Scanner/Software | pMEK(S217/221) | Normalized Median pMEK(S217/221) | pERK(T202/Y204) | Normalized Median pERK(T202/Y204) | p-p90RSK(S380) | Normalized Median p-p90RSK(S380) | p-p90RSK(T573) | Normalized Median p-p90RSK(T573) | p-AKT(T308) | Normalized Median p-AKT(T308) | p-AKT(S473) | Normalized Median p-AKT(S473) | p-mTOR(S2448) | Normalized Median p-mTOR(S2448) | p-p70S6K(T421/S424) | Normalized Median p-p70S6K(T421/S424) | p-p70S6K(T389) | Normalized Median p-p70S6K(T389) | p-S6(S235/236) | Normalized Median p-S6(S235/236) | p-AMPK(T172) | Normalized Median p-AMPK(T172) | p-JNK(T183/Y185) | Normalized Median p-JNK(T183/Y185) | Total c-Jun | Normalized Median Total c-Jun | p-cJun(S63) | Normalized Median p-cJun(S63) | p-P38(T180/Y182) | Normalized Median p-P38(T180/Y182) | p-HSP27(S82) | Normalized Median p-HSP27(S82) | p-NFKB(S536) | Normalized Median p-NFKB(S536) | Bim | Normalized Median Bim | cPARP | Normalized Median cPARP | p-Histone H3(S10) | Normalized Median p-Histone H3(S10) | p27 Kip1 | Normalized Median p27 Kip1 |
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SB590885 | COLO 858 | 0.1000 | uM | 24 | hr | 7 | Odyssey/Microvigene | 0.6803 | -0.5708 | 1.1976 | -0.2539 | 0.1319 | -0.0518 | 0.1890 | -0.1660 | 0.1381 | -0.0588 | 0.2049 | -0.2779 | 0.1783 | 0.1945 | 0.1887 | 0.1768 | 0.8130 | -0.0654 | 0.8130 | 0.6188 | 0.3345 | 0.2210 | 0.2049 | 0.4260 | 0.2451 | 0.7227 | 0.2058 | 0.0754 | 0.3378 | 0.1326 | 0.1754 | 0.7365 | 0.1949 | 0.5757 | 0.3597 | -0.4460 | 1.0682 | 0.7906 | ||||
SB590885 | COLO 858 | 0.1000 | uM | 24 | hr | 8 | Odyssey/Microvigene | 0.8065 | -0.5708 | 1.3351 | -0.2539 | 0.1376 | -0.0518 | 0.1667 | -0.1660 | 0.1339 | -0.0588 | -0.2779 | 0.1637 | 0.1945 | 0.2062 | 0.1768 | 1.1848 | -0.0654 | 0.8621 | 0.6188 | 0.3534 | 0.2210 | 0.1898 | 0.4260 | 0.2398 | 0.7227 | 0.2398 | 0.0754 | 0.3571 | 0.1326 | 0.1332 | 0.7365 | 0.1779 | 0.5757 | 0.4202 | -0.4460 | 1.0333 | 0.7906 | |||||
SB590885 | COLO 858 | 0.1000 | uM | 48 | hr | 1 | Odyssey/Microvigene | 0.6579 | -0.4674 | 1.4286 | -0.0149 | 0.3530 | 0.2770 | 0.1253 | 0.2463 | 0.2796 | 0.1988 | -0.2480 | 0.2695 | 0.2274 | 0.3115 | 0.1590 | 0.6579 | -0.6590 | 0.7407 | 0.4645 | 0.5435 | 0.3549 | 0.2833 | 0.7289 | 0.3636 | 0.9246 | 0.2639 | 0.1547 | 0.6061 | 0.4225 | 0.2571 | 1.1083 | 0.2114 | 0.8546 | 0.5682 | -0.2142 | 1.0644 | 0.8676 | |||||
SB590885 | COLO 858 | 0.1000 | uM | 48 | hr | 2 | Odyssey/Microvigene | 0.6024 | -0.4674 | 1.8282 | -0.0149 | 0.2451 | 0.3530 | 0.2283 | 0.1253 | 0.2762 | 0.2796 | 0.2310 | -0.2480 | 0.2274 | 0.1590 | 0.8929 | -0.6590 | 0.8000 | 0.4645 | 0.5556 | 0.3549 | 0.2551 | 0.7289 | 0.9246 | 0.2833 | 0.1547 | 0.6667 | 0.4225 | 1.1083 | 0.1949 | 0.8546 | 0.6211 | -0.2142 | 1.1257 | 0.8676 | ||||||||
SB590885 | COLO 858 | 0.1000 | uM | 48 | hr | 3 | Odyssey/Microvigene | 0.6173 | -0.4674 | 1.4728 | -0.0149 | 0.1724 | 0.3530 | 0.2513 | 0.1253 | 0.1880 | 0.2796 | 0.1923 | -0.2480 | 0.2375 | 0.2274 | 0.2710 | 0.1590 | 0.5780 | -0.6590 | 0.6536 | 0.4645 | 0.4975 | 0.3549 | 0.2740 | 0.7289 | 0.3584 | 0.9246 | 0.2817 | 0.1547 | 0.5780 | 0.4225 | 0.2114 | 1.1083 | 0.2151 | 0.8546 | 0.5587 | -0.2142 | 0.9622 | 0.8676 | ||||
SB590885 | COLO 858 | 0.1000 | uM | 48 | hr | 4 | Odyssey/Microvigene | 0.5618 | -0.4674 | 1.5291 | -0.0149 | 0.2075 | 0.3530 | 0.2558 | 0.1253 | 0.2132 | 0.2796 | 0.2079 | -0.2480 | 0.2364 | 0.2274 | 0.2786 | 0.1590 | 0.5376 | -0.6590 | 0.7874 | 0.4645 | 0.5181 | 0.3549 | 0.2874 | 0.7289 | 0.3802 | 0.9246 | 0.2688 | 0.1547 | 0.5682 | 0.4225 | 0.2268 | 1.1083 | 0.2398 | 0.8546 | 0.6061 | -0.2142 | 0.9401 | 0.8676 | ||||
SB590885 | COLO 858 | 0.1000 | uM | 48 | hr | 5 | Odyssey/Microvigene | 0.5495 | -0.4674 | 1.3351 | -0.0149 | 0.2137 | 0.3530 | 0.3030 | 0.1253 | 0.1524 | 0.2796 | 0.2105 | -0.2480 | 0.2105 | 0.2274 | 0.2404 | 0.1590 | 0.5682 | -0.6590 | 0.7634 | 0.4645 | 0.5051 | 0.3549 | 0.2793 | 0.7289 | 0.3597 | 0.9246 | 0.2825 | 0.1547 | 0.4651 | 0.4225 | 0.2597 | 1.1083 | 0.1855 | 0.8546 | 0.6623 | -0.2142 | 0.9427 | 0.8676 | ||||
SB590885 | COLO 858 | 0.1000 | uM | 48 | hr | 6 | Odyssey/Microvigene | 0.5376 | -0.4674 | 1.7182 | -0.0149 | 0.1946 | 0.3530 | 0.2364 | 0.1253 | 0.1984 | 0.2796 | 0.2404 | -0.2480 | 0.1942 | 0.2274 | 0.2786 | 0.1590 | 0.7299 | -0.6590 | 0.8265 | 0.4645 | 0.5208 | 0.3549 | 0.2660 | 0.7289 | 0.3690 | 0.9246 | 0.3077 | 0.1547 | 0.5376 | 0.4225 | 0.1969 | 1.1083 | 0.1961 | 0.8546 | 0.5291 | -0.2142 | 1.0340 | 0.8676 | ||||
SB590885 | COLO 858 | 0.1000 | uM | 48 | hr | 7 | Odyssey/Microvigene | 0.6289 | -0.4674 | 1.3661 | -0.0149 | 0.1715 | 0.3530 | 0.2326 | 0.1253 | 0.1776 | 0.2796 | 0.1942 | -0.2480 | 0.2079 | 0.2274 | 0.2551 | 0.1590 | 0.6061 | -0.6590 | 0.6623 | 0.4645 | 0.4831 | 0.3549 | 0.2416 | 0.7289 | 0.3677 | 0.9246 | 0.2833 | 0.1547 | 0.5102 | 0.4225 | 0.2083 | 1.1083 | 0.2398 | 0.8546 | 0.5076 | -0.2142 | 1.0315 | 0.8676 | ||||
SB590885 | COLO 858 | 0.1000 | uM | 48 | hr | 8 | Odyssey/Microvigene | 0.5882 | -0.4674 | 1.4577 | -0.0149 | 0.1812 | 0.3530 | 0.2370 | 0.1253 | 0.1901 | 0.2796 | 0.2433 | -0.2480 | 0.2203 | 0.2274 | 0.2632 | 0.1590 | 0.5376 | -0.6590 | 0.7092 | 0.4645 | 0.4630 | 0.3549 | 0.2571 | 0.7289 | 0.3497 | 0.9246 | 0.2967 | 0.1547 | 0.4951 | 0.4225 | 0.2165 | 1.1083 | 0.2169 | 0.8546 | 0.5495 | -0.2142 | 1.0573 | 0.8676 | ||||
SB590885 | COLO 858 | 0.3160 | uM | 1 | hr | 1 | Odyssey/Microvigene | 0.3135 | -1.4105 | 0.5076 | -1.6902 | 0.1110 | -0.3331 | 0.1667 | -0.3316 | 0.1318 | -0.2476 | 0.5128 | 0.9911 | 0.1645 | -0.0587 | 0.3145 | 0.6055 | 1.7422 | 0.6321 | 0.5714 | -0.0798 | 0.4484 | 0.2221 | 0.1309 | -0.1606 | 0.1770 | 0.0280 | 0.2114 | -0.3761 | 0.4310 | 0.0515 | 0.0952 | -0.0762 | 0.1232 | -0.0219 | 0.5291 | -0.1904 | 0.6897 | 0.0128 | ||||
SB590885 | COLO 858 | 0.3160 | uM | 1 | hr | 2 | Odyssey/Microvigene | 0.3597 | -1.4105 | 0.5780 | -1.6902 | 0.1198 | -0.3331 | 0.1773 | -0.3316 | 0.1348 | -0.2476 | 0.5587 | 0.9911 | 0.1560 | -0.0587 | 0.3546 | 0.6055 | 1.7730 | 0.6321 | 0.7042 | -0.0798 | 0.4405 | 0.2221 | 0.1256 | -0.1606 | 0.1976 | 0.0280 | 0.2028 | -0.3761 | 0.4167 | 0.0515 | 0.1319 | -0.0762 | 0.1504 | -0.0219 | 0.6849 | -0.1904 | 0.7383 | 0.0128 | ||||
SB590885 | COLO 858 | 0.3160 | uM | 1 | hr | 3 | Odyssey/Microvigene | 0.2882 | -1.4105 | 0.4651 | -1.6902 | 0.1927 | -0.3331 | 0.2809 | -0.3316 | 0.1456 | -0.2476 | 0.4673 | 0.9911 | 0.1984 | -0.0587 | 0.3876 | 0.6055 | 1.4164 | 0.6321 | 0.4651 | -0.0798 | 0.5025 | 0.2221 | 0.1883 | -0.1606 | 0.1931 | 0.0280 | 0.1842 | -0.3761 | 0.4237 | 0.0515 | -0.0762 | 0.1403 | -0.0219 | 0.8000 | -0.1904 | 0.5704 | 0.0128 | |||||
SB590885 | COLO 858 | 0.3160 | uM | 1 | hr | 4 | Odyssey/Microvigene | 0.2564 | -1.4105 | 0.3401 | -1.6902 | 0.1221 | -0.3331 | 0.1783 | -0.3316 | 0.1701 | -0.2476 | 0.4808 | 0.9911 | 0.2717 | -0.0587 | 0.4651 | 0.6055 | 1.2755 | 0.6321 | 0.5025 | -0.0798 | 0.4854 | 0.2221 | 0.1689 | -0.1606 | 0.2020 | 0.0280 | 0.2326 | -0.3761 | 0.4630 | 0.0515 | 0.0813 | -0.0762 | 0.0781 | -0.0219 | 0.6944 | -0.1904 | 0.4565 | 0.0128 | ||||
SB590885 | COLO 858 | 0.3160 | uM | 1 | hr | 5 | Odyssey/Microvigene | 0.3584 | -1.4105 | 0.4525 | -1.6902 | 0.1000 | -0.3331 | 0.1280 | -0.3316 | 0.1100 | -0.2476 | 0.4975 | 0.9911 | 0.1311 | -0.0587 | 0.2632 | 0.6055 | 1.4749 | 0.6321 | 0.5291 | -0.0798 | 0.3650 | 0.2221 | 0.1109 | -0.1606 | 0.1333 | 0.0280 | 0.1808 | -0.3761 | 0.3636 | 0.0515 | 0.0446 | -0.0762 | 0.1106 | -0.0219 | 0.4115 | -0.1904 | 0.6084 | 0.0128 | ||||
SB590885 | COLO 858 | 0.3160 | uM | 1 | hr | 6 | Odyssey/Microvigene | 0.3891 | -1.4105 | 0.5263 | -1.6902 | 0.0971 | -0.3331 | 0.1040 | -0.3316 | 0.1280 | -0.2476 | 0.5376 | 0.9911 | 0.1359 | -0.0587 | 0.3145 | 0.6055 | 1.4225 | 0.6321 | 0.6897 | -0.0798 | 0.3247 | 0.2221 | 0.1323 | -0.1606 | 0.1484 | 0.0280 | 0.1477 | -0.3761 | 0.3448 | 0.0515 | 0.0794 | -0.0762 | 0.1220 | -0.0219 | 0.4717 | -0.1904 | 0.5561 | 0.0128 | ||||
SB590885 | COLO 858 | 0.3160 | uM | 1 | hr | 7 | Odyssey/Microvigene | 0.3058 | -1.4105 | 0.4016 | -1.6902 | 0.1479 | -0.3331 | 0.2155 | -0.3316 | 0.1464 | -0.2476 | 0.4902 | 0.9911 | 0.2519 | -0.0587 | 0.3846 | 0.6055 | 1.5576 | 0.6321 | 0.4630 | -0.0798 | 0.5208 | 0.2221 | 0.1605 | -0.1606 | 0.2151 | 0.0280 | 0.1890 | -0.3761 | 0.5465 | 0.0515 | 0.1862 | -0.0762 | 0.1020 | -0.0219 | 0.5348 | -0.1904 | 0.5718 | 0.0128 | ||||
SB590885 | COLO 858 | 0.3160 | uM | 1 | hr | 8 | Odyssey/Microvigene | 0.2695 | -1.4105 | 0.3922 | -1.6902 | 0.1795 | -0.3331 | 0.1923 | -0.3316 | -0.2476 | 0.4329 | 0.9911 | 0.2660 | -0.0587 | 0.5000 | 0.6055 | 1.2048 | 0.6321 | 0.4739 | -0.0798 | 0.5682 | 0.2221 | 0.1815 | -0.1606 | 0.2513 | 0.0280 | 0.2237 | -0.3761 | 0.5587 | 0.0515 | 0.1513 | -0.0762 | 0.1105 | -0.0219 | 0.6135 | -0.1904 | 0.4860 | 0.0128 | |||||
SB590885 | COLO 858 | 0.3160 | uM | 5 | hr | 1 | Odyssey/Microvigene | 0.3290 | -1.1755 | 1.2240 | -0.2673 | 0.1391 | -0.0080 | 0.2364 | 0.1821 | 0.1754 | 0.0954 | 0.6536 | 1.3813 | 0.2137 | 0.2583 | 0.4926 | 1.0940 | 1.0893 | 0.0278 | 0.4902 | -0.0616 | 0.5128 | 0.3585 | 0.1645 | 0.2122 | 0.2212 | 0.3000 | 0.2283 | -0.2712 | 0.4739 | 0.2636 | 0.1427 | 0.9591 | 0.1529 | 0.3551 | 0.7752 | 0.5231 | 0.8175 | 0.3319 | ||||
SB590885 | COLO 858 | 0.3160 | uM | 5 | hr | 2 | Odyssey/Microvigene | 0.3731 | -1.1755 | 1.2594 | -0.2673 | 0.1443 | -0.0080 | 0.2387 | 0.1821 | 0.1792 | 0.0954 | 0.6711 | 1.3813 | 0.2347 | 0.2583 | 0.5181 | 1.0940 | 0.9804 | 0.0278 | 0.5465 | -0.0616 | 0.5208 | 0.3585 | 0.1613 | 0.2122 | 0.2353 | 0.3000 | 0.2020 | -0.2712 | 0.4854 | 0.2636 | 0.1905 | 0.9591 | 0.3551 | 0.9615 | 0.5231 | 0.8048 | 0.3319 | |||||
SB590885 | COLO 858 | 0.3160 | uM | 5 | hr | 3 | Odyssey/Microvigene | 0.3559 | -1.1755 | 1.0571 | -0.2673 | 0.2653 | -0.0080 | 0.1821 | 0.1482 | 0.0954 | 0.6944 | 1.3813 | 0.2188 | 0.2583 | 0.4902 | 1.0940 | 0.7874 | 0.0278 | 0.4975 | -0.0616 | 0.5155 | 0.3585 | 0.2151 | 0.2122 | 0.2203 | 0.3000 | 0.1783 | -0.2712 | 0.4237 | 0.2636 | 0.2096 | 0.9591 | 0.1637 | 0.3551 | 1.0030 | 0.5231 | 0.7131 | 0.3319 | |||||
SB590885 | COLO 858 | 0.3160 | uM | 5 | hr | 4 | Odyssey/Microvigene | 0.4032 | -1.1755 | 1.2361 | -0.2673 | 0.1565 | -0.0080 | 0.2646 | 0.1821 | 0.1704 | 0.0954 | 0.6494 | 1.3813 | 0.2198 | 0.2583 | 0.5181 | 1.0940 | 0.9901 | 0.0278 | 0.5348 | -0.0616 | 0.4902 | 0.3585 | 0.1883 | 0.2122 | 0.2342 | 0.3000 | 0.2037 | -0.2712 | 0.4951 | 0.2636 | 0.1221 | 0.9591 | 0.1565 | 0.3551 | 0.9174 | 0.5231 | 0.6748 | 0.3319 | ||||
SB590885 | COLO 858 | 0.3160 | uM | 5 | hr | 5 | Odyssey/Microvigene | 0.3135 | -1.1755 | 1.1876 | -0.2673 | 0.1466 | -0.0080 | 0.2710 | 0.1821 | 0.1585 | 0.0954 | 0.6452 | 1.3813 | 0.2165 | 0.2583 | 0.4878 | 1.0940 | 0.8475 | 0.0278 | 0.5208 | -0.0616 | 0.5181 | 0.3585 | 0.1623 | 0.2122 | 0.2364 | 0.3000 | 0.2488 | -0.2712 | 0.5465 | 0.2636 | 0.1036 | 0.9591 | 0.1287 | 0.3551 | 0.8475 | 0.5231 | 0.7011 | 0.3319 | ||||
SB590885 | COLO 858 | 0.3160 | uM | 5 | hr | 6 | Odyssey/Microvigene | 0.3226 | -1.1755 | 1.3298 | -0.2673 | 0.1346 | -0.0080 | 0.2278 | 0.1821 | 0.1709 | 0.0954 | 0.6289 | 1.3813 | 0.2304 | 0.2583 | 0.5556 | 1.0940 | 0.7937 | 0.0278 | 0.5435 | -0.0616 | 0.4808 | 0.3585 | 0.2123 | 0.2122 | 0.2732 | 0.3000 | 0.2062 | -0.2712 | 0.5000 | 0.2636 | 0.2000 | 0.9591 | 0.1409 | 0.3551 | 0.9709 | 0.5231 | 0.6716 | 0.3319 | ||||
SB590885 | COLO 858 | 0.3160 | uM | 5 | hr | 7 | Odyssey/Microvigene | 0.3846 | -1.1755 | 1.0482 | -0.2673 | 0.2083 | -0.0080 | 0.3003 | 0.1821 | 0.2070 | 0.0954 | 0.6061 | 1.3813 | 0.3759 | 0.2583 | 0.5435 | 1.0940 | 0.9259 | 0.0278 | 0.4739 | -0.0616 | 0.3585 | 0.1890 | 0.2122 | 0.2488 | 0.3000 | 0.2151 | -0.2712 | 0.5780 | 0.2636 | 0.2611 | 0.9591 | 0.1508 | 0.3551 | 0.8772 | 0.5231 | 0.7118 | 0.3319 |