Pacritinib - Small Molecule (ID:10381-101)

HMS LINCS ID: 10381-101
Name: Pacritinib
Alternative Names: SB1518
LINCS ID:
PubChem CID: 46216796
ChEBI ID:
ChEMBL ID:
Molecular Mass: 472.25
InChi: InChI=1S/C28H32N4O3/c1-2-13-32(12-1)14-17-35-27-9-8-25-19-24(27)21-34-16-4-3-15-33-20-22-6-5-7-23(18-22)26-10-11-29-28(30-25)31-26/h3-11,18-19H,1-2,12-17,20-21H2,(H,29,30,31)
InChi Key: HWXVIOGONBBTBY-UHFFFAOYSA-N
SMILES: C1CCN(C1)CCOC2=C3COCC=CCOCC4=CC=CC(=C4)C5=NC(=NC=C5)NC(=C3)C=C2
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
FLT3, JAK2, TYK2
2
(equivalent to 100 nM ≤ Kd < 1µM)
JAK3
3
(equivalent to 1µM ≤ Kd < 10 µM)
CCNA1, CCNA2, CDK2, JAK1

Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10381-101-1 MedChem Express 12003