Baricitinib - Small Molecule (ID:10354-101)

HMS LINCS ID: 10354-101
Name: Baricitinib
Alternative Names: INCB028050; LY3009104
LINCS ID: LSM-6709
PubChem CID: 44205240
ChEBI ID:
ChEMBL ID:
Molecular Mass: 371.12
InChi: InChI=1S/C16H17N7O2S/c1-2-26(24,25)22-9-16(10-22,4-5-17)23-8-12(7-21-23)14-13-3-6-18-15(13)20-11-19-14/h3,6-8,11H,2,4,9-10H2,1H3,(H,18,19,20)
InChi Key: XUZMWHLSFXCVMG-UHFFFAOYSA-N
SMILES: CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
JAK1, JAK2, TYK2
2
(equivalent to 100 nM ≤ Kd < 1µM)
BMP2K, CAMK2A, JAK3, MAP3K2, PRPF4B, ROCK1, ROCK2
10
(confirmed non-binding)
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Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20227
Baricitinib KINOMEscan
KINOMEscan
20369
Binding affinity of 6 small molecule JAK inhibitors for 5 kinases
Affinity Data

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10354-101-1 Selleck Chemicals S285101