PF 573228 - Small Molecule (ID:10199-101)

HMS LINCS ID: 10199-101
Name: PF 573228
Alternative Names:
LINCS ID: LSM-1200
PubChem CID: 11612883
ChEBI ID:
ChEMBL ID:
Molecular Mass: 491.12
InChi: InChI=1S/C22H20F3N5O3S/c1-34(32,33)16-4-2-3-13(9-16)11-26-20-17(22(23,24)25)12-27-21(30-20)28-15-6-7-18-14(10-15)5-8-19(31)29-18/h2-4,6-7,9-10,12H,5,8,11H2,1H3,(H,29,31)(H2,26,27,28,30)
InChi Key: HESLKTSGTIBHJU-UHFFFAOYSA-N
SMILES: CS(=O)(=O)C1=CC=CC(=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)CC4
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
PTK2
2
(equivalent to 100 nM ≤ Kd < 1µM)
CDK1, CDK7, Ptk2
3
(equivalent to 1µM ≤ Kd < 10 µM)
GSK3B, PTK2B

Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20275
Phosphorylation state and protein levels measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (immunofluorescence dataset 2 of 4)
Microscopy/Imaging

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10199-101-1 Tocris
10199-101-2 Selleck Chemicals