KW2449 - Small Molecule (ID:10192-999)

HMS LINCS ID: 10192-999
Name: KW2449
Alternative Names: KW-2449
LINCS ID: LSM-42803
PubChem CID: 67089852
ChEBI ID:
ChEMBL ID:
Molecular Mass: 332.16
InChi: InChI=1S/C20H20N4O/c25-20(24-13-11-21-12-14-24)16-8-5-15(6-9-16)7-10-19-17-3-1-2-4-18(17)22-23-19/h1-10,21H,11-14H2,(H,22,23)
InChi Key: YYLKKYCXAOBSRM-UHFFFAOYSA-N
SMILES: C1CN(CCN1)C(=O)C2=CC=C(C=C2)C=CC3=NNC4=CC=CC=C43
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2018-03-30

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
AAK1, ABL1, AIM1, ANKK1, AURKB, AURKC, BMP2K, C8orf44-SGK3, CHEK2, CLK1, CLK2, CLK4, DCLK3, FLT1, FLT3, GRK4, IRAK1, JAK2, JAK3, KIT, MAP3K12, MAP3K19, MAP3K2, MAP3K7, MAP4K1, MAP4K2, MAP4K4, MAPK10, MINK1, MYLK2, MYLK3, NUAK2, PDGFRB, PIP4K2B, PIP5K1A, PLK4, RET, RIOK1, RIOK3, RIPK1, SGK3, SLK, SRPK1, SRPK2, STK10, STK16, STK17A, STK17B, TNIK, ULK1, YES1
2
(equivalent to 100 nM ≤ Kd < 1µM)
ABL2, ACVR1, ACVR2A, ACVR2B, ALK, AURKA, AXL, BMPR1B, BMPR2, CAMK1D, CAMKK1, CAMKK2, CDK14, CDK16, CDK4, CDK7, CHEK1, CHUK, CIT, CSF1R, CSNK1E, CSNK1G2, CSNK2A2, DAPK1, DAPK3, DSTYK, DYRK1A, DYRK1B, DYRK2, EIF2AK4, EPHA1, EPHA3, EPHA7, EPHB6, FES, FGFR1, FGFR2, FGFR3, FGR, FLG, FYN, GAK, HIPK1, HIPK2, HIPK3, HUNK, IGF1R, IKBKB, IKBKE, INSR, INSRR, IRAK3, IRAK4, ITK, JAK1, KDR, LRRK2, LTK, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP3K11, MAP3K13, MAP3K20, MAP3K3, MAP3K9, MAP4K3, MAP4K5, MAPK8, MAPK9, MARK1, MARK2, MARK4, MELK, MERTK, MET, MST1, MST1R, MUSK, MYLK, MYLK4, MYO3A, NEK6, NEK7, NEK8, NEK9, NTRK1, NTRK2, NTRK3, PAK3, PAK5, PDGFRA, PDK1, PDPK1, PHKG1, PHKG2, PKN1, PKN2, pknB, PRKAA1, PRKAA2, PRKD3, PRKG2, PRPF4B, PTK2B, RIPK4, ROCK1, ROCK2, RPS6KA3, RPS6KA6, RPS6KB1, SBK1, SBK3, SIK1, SIK1B, SIK2, SRPK3, STK11, STK33, STK35, STK38, STK39, STK4, SYK, TBK1, TIE1, TNK1, TPTEP2-CSNK1E, TTK, TXK, TYK2, ULK2, ULK3, ZAP70
3
(equivalent to 1µM ≤ Kd < 10 µM)
BLK, BMPR1A, BMX, BRSK1, BRSK2, BTK, BUB1B-PAK6, CAMK1, CAMK1G, CAMK2A, CDC42BPG, CDK15, CDK17, CDKL2, CLK3, CSK, CSNK1A1, CSNK1D, CSNK1G1, CSNK1G3, CSNK2A1, DAPK2, DCLK1, DDR1, DDR2, DMPK, EGFR, EIF2AK2, EPHA2, EPHA6, EPHB1, EPHB4, ERN1, FER, FGFR4, FLT4, FRK, GRK7, HCK, HIPK4, ICK, LATS1, LATS2, LCK, LYN, MAP3K10, MAP3K4, MAPK11, MAPK15, MAPK6, MAPK7, MAPKAPK5, MARK3, MATK, MKNK2, MYO3B, NEK1, NEK2, NEK3, NEK4, NEK5, NIM1K, OSR1, OXSR1, PAK1, PAK2, PAK4, PAK6, PF3D7_0217500, PKD1, PKD2, PRKD1, PRKD2, PRKG1, PRKX, PTK2, RIOK2, RIPK2, RPS6KA1, RPS6KA2, RPS6KA4, RPS6KA5, SIK3, SRC, SRMS, STK24, STK25, STK26, STK3, STK32A, STK38L, TAOK1, TAOK3, TEK, TKT, TLK1, TLK2, TNK2, TSSK1B, WEE1, WEE2
10
(confirmed non-binding)
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Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20185
KW-2449 KINOMEscan
KINOMEscan

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10192-999-2