Sunitinib - Small Molecule (ID:10175-106)

HMS LINCS ID: 10175-106
Name: Sunitinib
Alternative Names: Sutent; SU11248
LINCS ID: LSM-42800
PubChem CID: 3086686
ChEBI ID:
ChEMBL ID: 535
Molecular Mass: 398.21
InChi: InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)
InChi Key: WINHZLLDWRZWRT-UHFFFAOYSA-N
SMILES: CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2018-03-30

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
AAK1, AXL, BLK, BMP2K, CAMK2A, CHEK2, CLK1, CLK2, CLK4, CSF1R, CSNK1A1, CSNK1D, CSNK1E, DAPK3, FLT1, FLT3, FLT4, GAK, HIPK1, HIPK2, HIPK3, IRAK1, IRAK4, ITK, JAK1, KDR, KIT, LRRK2, MAP2K5, MAP3K13, MAP3K19, MAP3K2, MAP3K7, MAP4K1, MAP4K2, MAP4K5, MERTK, MINK1, MST1, MYLK2, MYLK3, MYLK4, NUAK1, PAK3, PDGFRA, PDGFRB, PHKG1, PHKG2, PIP4K2B, pknB, PRKAA1, PRKAA2, PTK2B, RET, RIOK1, RIOK2, RPS6KA2, RPS6KB1, SLK, SRPK3, STK10, STK11, STK17A, STK24, STK3, STK33, STK4, TNIK, TPTEP2-CSNK1E, TTK, TYRO3, ULK1, ULK2, ULK3
2
(equivalent to 100 nM ≤ Kd < 1µM)
ABL1, AIM1, ALK, ANKK1, AURKB, AURKC, BMPR2, C8orf44-SGK3, CAMK1, CAMK1D, CAMK1G, CAMK2D, CAMK2G, CAMK4, CAMKK1, CDK14, CDK16, CDK7, CHEK1, CHUK, CSNK1A1L, CSNK1D, CSNK1G1, CSNK1G2, CSNK1G3, CSNK2A1, CSNK2A2, DAPK1, DAPK2, DCLK1, DCLK3, DLK1, DYRK1A, DYRK2, EIF2AK2, EIF2AK4, EPHA6, EPHB1, EPHB6, ERN1, FES, FGFR1, FGFR2, FGFR3, FGR, FLG, FRK, FYN, GCK, GRK1, GRK4, GRK7, HCK, HIPK4, HUNK, ICK, IGF1R, IKBKE, INSR, INSRR, IRAK3, JAK2, KCNH2, LATS1, LATS2, LCK, LYN, MAP2K1, MAP2K1, MAP2K2, MAP2K4, MAP3K11, MAP3K12, MAP3K3, MAP4K3, MAP4K4, MARK2, MARK3, MAST1, MELK, MUSK, MYLK, NIM1K, NTRK1, NTRK2, NUAK2, OSR1, OXSR1, PAK5, PHKA2, PKD1, PKD2, PKN1, PLK4, PRKAB1, PRKAB2, PRKD1, PRKD2, PRKD3, PRPF4, PRPF4B, PTK2, RIPK1, ROCK1, ROCK2, RPS6KA1, RPS6KA3, RPS6KA4, RPS6KA5, SBK1, SGK2, SGK3, SIK2, SNRK, SRC, SRPK1, SRPK2, STK16, STK17B, STK25, STK26, Stk3, STK38, STK38L, STK39, TAOK1, TAOK3, TBK1, TLK1, TLK2, TNK1, TSSK2, TYK2, Ulk3, YES1
3
(equivalent to 1µM ≤ Kd < 10 µM)
ABL2, AKT2, AURKA, BMPR1B, BRSK1, BRSK2, BTK, BUB1B-PAK6, CAMK2B, CAMKK2, CDC7, CDK1, CDK17, CDK18, CDK4, CDK5, CDKL2, CIT, DCLK2, DDR1, DDR2, DSTYK, DYRK1B, DYRK3, DYRK4, EEF2K, EGFR, EPHA3, EPHA5, EPHA7, EPHB4, FER, FGFR4, GRK5, JAK3, LTK, MAP2K3, MAP2K6, MAP3K15, MAP3K4, MAP3K9, MAPK10, MAPK7, MAPK9, MARK1, MARK4, MATK, MET, MKNK1, MKNK2, MYO3A, MYO3B, NEK2, NEK4, NEK7, NTRK3, PAK4, PAK6, PDK1, PDPK1, PF3D7_0217500, PIM3, PIP5K1A, PKN2, PLK2, PRKCA, PRKCG, PRKCI, PRKCQ, PRKCZ, PTK6, RIOK3, RIPK4, RPS6KA6, SBK3, SIK1, SIK1B, SRC, STK35, TIE1, TNK2, TNKS2, TSSK1B, WEE1
10
(confirmed non-binding)
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Batch Information for HMSL10175-106-4:

HMS LINCS Batch ID: 10175-106-4
Provider: Haoyuan chemexpress
Provider Batch ID: 08828
Salt: 106
Molecular Formula: C26H33FN4O7
Molecular Weight: 532.56
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2015-05-14
Most Recent Update: 2016-04-04

HMS QC Testing Events for HMSL10175-106-4:

Date HMS QC Outcome Comment Files
05/04/2015 PASS HMSL10175-106-4_NMR.pdf,
HMSL10175-106-4_LCMS.pdf