Momelotinib - Small Molecule (ID:10140-114)

HMS LINCS ID: 10140-114
Name: Momelotinib
Alternative Names: CYT387
LINCS ID: LSM-1141
PubChem CID: 25062766
ChEBI ID:
ChEMBL ID:
Molecular Mass: 414.18
InChi: InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)
InChi Key: ZVHNDZWQTBEVRY-UHFFFAOYSA-N
SMILES: C1COCCN1C2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CC=C(C=C4)C(=O)NCC#N
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-07-12

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
JAK1, JAK2
2
(equivalent to 100 nM ≤ Kd < 1µM)
CHUK, JAK3, MYLK4, RIOK3
10
(confirmed non-binding)
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Batch Information for HMSL10140-114-2:

HMS LINCS Batch ID: 10140-114-2
Provider: MedChem Express
Provider Batch ID: 03454
Salt: 114
Molecular Formula: C23H26N6O10S2
Molecular Weight: 610.62
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2015-06-17
Most Recent Update: 2016-04-04

HMS QC Testing Events for HMSL10140-114-2:

Date HMS QC Outcome Comment Files
08/31/2015 PASS HMSL10140-114-2_LCMS.pdf