NVP-TAE684 - Small Molecule (ID:10024-999)

HMS LINCS ID: 10024-999
Name: NVP-TAE684
Alternative Names: TAE-684
LINCS ID: LSM-1024
PubChem CID: 16038120
ChEBI ID:
ChEMBL ID: 509032
Molecular Mass: 613.26
InChi: InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)
InChi Key: QQWUGDVOUVUTOY-UHFFFAOYSA-N
SMILES: CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-07-12

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
ABL1, ACVR1, ACVR1B, ACVRL1, Alk, ALK, AURKA, AURKC, AXL, BLK, BMPR1B, BTK, CAMK4, CAMKK1, CAMKK2, CHEK1, CHEK2, CLK1, CLK2, CLK4, COQ8B, CSF1R, DCLK1, DCLK2, DCLK3, DSTYK, EGFR, EPHA1, FER, FES, FGFR1, FLT3, FLT4, FRK, GAK, IGF1R, INSR, INSRR, IRAK1, IRAK4, ITK, JAK2, JAK3, LCK, LRRK2, LTK, MAP3K12, MAP3K13, MAP4K3, MAPK10, MAPK7, MARK1, MARK2, MARK3, MARK4, MELK, MERTK, MKNK2, MYO3A, MYO3B, NUAK1, NUAK2, OSR1, OXSR1, PAK3, PHKG1, PHKG2, PKD1, PLK1, PLK4, PRKAA1, PRKAA2, PRKD1, PRKD3, PTK2, PTK2B, PTK6, ROCK1, ROS1, RPS6KA2, RPS6KA3, RPS6KA6, SBK1, SBK3, SIK1, SIK1B, SIK2, SLK, STK10, STK32A, STK32B, STK32C, STK33, TAOK1, TAOK3, TEK, TIE1, TNK1, TNK2, TSSK1B, TSSK2, TTK, ULK1, ULK2, ULK3, YES1
2
(equivalent to 100 nM ≤ Kd < 1µM)
AAK1, ABL2, AIM1, AURKB, BMPR1A, BRSK1, BRSK2, CAMK1, CAMK1D, CAMK2A, CAMK2D, CAMK2G, CASK, CDK1, CDK16, CDK17, CDK4, CDK5, CDK7, CLK3, DAPK2, DDR1, EPHA2, EPHA4, EPHA6, EPHA7, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, ERBB2, ERBB4, ERN1, FGFR2, FGFR3, FGFR4, FGR, FLG, FLT1, FYN, GCK, GRK1, GRK5, GRK7, HCK, HIPK4, HUNK, IRAK3, JAK1, KDR, KIT, LIMK1, LYN, MAP2K1, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP3K11, MAP3K15, MAP3K2, MAP3K3, MAP3K7, MAP3K9, MAP4K1, MAP4K2, MAP4K4, MAP4K5, MAPK1, MAPK15, MAPK3, MAPK8, MAPK9, MET, MINK1, MST1, MST1R, MUSK, MYLK, NEK8, NEK9, NTRK1, NTRK2, PAK1, PAK5, PDGFRA, PDGFRB, PF3D7_0217500, PHKA2, PI4KB, PKD2, PKN1, PKN2, PLK3, PRKD2, PRKG1, PRKG2, RET, ROCK2, RPS6KA1, SNRK, SRC, SRC, SRMS, STK16, STK26, STK3, STK35, STK38, STK38L, STK39, STK4, SYK, TAOK2, TBK1, TEC, TGFBR1, TGFBR2, TXK, TYK2
3
(equivalent to 1µM ≤ Kd < 10 µM)
ACVR2A, ACVR2B, AKT1, AKT2, ANKK1, BMP2K, BMPR2, BMX, BUB1B-PAK6, CAMK1G, CAMK2B, CDC42BPA, CDC42BPB, CDC42BPG, CDC7, CDK15, CDK2, CDK8, CDK9, COQ8A, CSK, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1G1, CSNK1G2, CSNK1G3, CSNK2A1, CSNK2A2, DAPK1, DAPK3, DDR2, DMPK, DYRK1A, DYRK1B, DYRK3, DYRK4, EIF2AK4, EPHA3, EPHA5, FPGT-TNNI3K, GRK4, GSK3A, GSK3B, HIPK1, HIPK2, HIPK3, ICK, IKBKE, Insr, KARS, LATS1, LATS2, LIMK2, MAP2K6, MAP3K1, MAP3K10, MAP3K19, MAP3K4, MAP3K6, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MAST1, MATK, NEK2, NEK3, NEK4, NEK6, NEK7, NIM1K, NTRK3, PAK2, PAK4, PAK6, PDK1, PDPK1, PIM1, PIM2, PIM3, PIP4K2C, PIP5K1A, pknB, PLK2, PRKACA, PRKACB, PRKCD, PRKCE, PRKCG, PRKCI, PRKCQ, PRKX, PRPF4B, RIOK3, RIPK2, RIPK4, RPS6KA4, RPS6KB1, SIK3, SRPK1, SRPK3, STK17A, STK17B, STK24, STK25, STK36, TKT, TNIK, TNNI3K, TYRO3, WEE1, ZAP70
10
(confirmed non-binding)
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Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20199
TAE-684 KINOMEscan
KINOMEscan

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10024-999-3